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Bowel Preparation May Lead to a Higher Feasibility of Intestinal Infection

NCT05277090 · Status: UNKNOWN · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2022-03-14

No results posted yet for this study

Summary

An adequate bowel preparation is essential for a high quality of colonscopy. Nowdays, polyethyleneglyco is considered the most safe drug for bowel preparation, and is widely used around the world. However, previous study illustrated that bowel preparation by polyethyleneglyco could lead to qualitative changes in the intestinal microbiota both in mice and human. This study is aimed to investigate wether the changes in the intestinal microbiota could lead to a higher rate of intestinal infection.

Conditions

  • Healthy

Interventions

DRUG

2L of polyethyleneglycol

2L of polyethyleneglycol

DIETARY_SUPPLEMENT

inulin

15g inulin per day

COMBINATION_PRODUCT

probiotic combination product

participants take 2L of polyethyleneglycol, subsequently take 15g probiotics combination product (including Bifidobacterium lactis, Lactobacillus plantarum, inlulin, Vitamin C) per day. The probiotic combination product, named "Mei Ri Yi Jun" was produced by Wedge Pharmaceuticals.

Sponsors & Collaborators

  • Yanqing Li

    lead OTHER

Principal Investigators

  • Guanjun Kou · Qilu Hospital of Shandong University

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-03-15
Primary Completion
2022-03-15
Completion
2022-03-15

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05277090 on ClinicalTrials.gov