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Individual Risk Profiles for Adverse Drug Reactions in Geriatric Patients

NCT05247814 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 2000

Last updated 2022-06-23

No results posted yet for this study

Summary

This project will generate a prospective cohort of geriatric patients with polypharmacy which will be characterized for vulnerability profiles of adverse drug reactions.

Conditions

  • Polypharmacy
  • Pharmacogenetics
  • Pharmacogenomic Testing
  • Drug-Related Side Effects and Adverse Reactions

Interventions

GENETIC

Pharmacogenomic testing of a panel of important pharmacogenes to detect genetic variants and evaluate the association between genetically predicted and measured drug metabolism

All planned interventions are explorative analyses of biological and genetic risk profiles that can contribute to patients' individual risk for adverse drug reactions, i.e. due to variability in drug metabolism

OTHER

Adverse Drug Reaction detection

During appointments in the university outpatient clinic, patients will undergo a comprehensive adverse drug reaction (ADR) assessment based on an ADR diary they were handed at enrolment

OTHER

Falls Efficacy Scale International (FES-I)

The FES-I wil be obtained to estimate fear of falling

Sponsors & Collaborators

  • B. Braun Foundation

    collaborator OTHER

  • RWTH Aachen University

    lead OTHER

Principal Investigators

  • Julia C. Stingl, MD, ScD · Institute of Clinical Pharmacology, University Hospital RWTH Aachen

Eligibility

Min Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-07-31
Primary Completion
2032-02-29
Completion
2032-02-29

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05247814 on ClinicalTrials.gov