A Study of AC176 for the Treatment of Metastatic Castration Resistant Prostate Cancer
NCT05241613 · Status: TERMINATED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 28
Last updated 2025-02-13
Summary
This clinical trial is evaluating a drug called AC176 in participants with metastatic castration resistant prostate cancer (mCRPC) who have progressed on at least two prior systemic therapies.
The main goals of this study are to:
* Identify the recommended dose of AC176 that can be given safely to participants
* Evaluate the side effects of AC176
* Evaluate pharmacokinetics of AC176
* Evaluate the effectiveness of AC176
Conditions
- Metastatic Castration Resistant Prostate Cancer
Interventions
- DRUG
-
AC176
AC176 will be given orally (PO) on a 28-day cycle.
Sponsors & Collaborators
-
Accutar Biotechnology Inc
lead INDUSTRY
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- MALE
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2022-03-16
- Primary Completion
- 2024-03-05
- Completion
- 2024-03-05
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
A Clinical Study of ONCT-534 in Subjects With Metastatic Castration-resistant Prostate Cancer.
NCT05917470 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Trial of RNActive®-Derived Prostate Cancer Vaccine in Metastatic Castrate-refractory Prostate Cancer
NCT01817738 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Safety, Tolerability, Pharmacokinetics, and Efficacy of Acapatamab in Subjects With mCRPC
NCT03792841 ·Status: TERMINATED ·Phase: PHASE1
-
Study of Abiraterone Acetate in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC), Chemo-Naive, Who Received a Prior Diethylstilbestrol Therapy
NCT02217566 ·Status: COMPLETED ·Phase: PHASE2
-
Bicalutamide With or Without Akt Inhibitor MK2206 in Treating Patients With Previously Treated Prostate Cancer
NCT01251861 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Phase II Study of Increased-Dose Abiraterone Acetate in Patients With Castration Resistant Prostate Cancer
NCT01637402 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of Abiraterone Acetate Plus Prednisone in Patients With Metastatic Castration-Resistant Prostate Cancer Who Have Failed Docetaxel-Based Chemotherapy
NCT01695135 ·Status: COMPLETED ·Phase: PHASE3
-
Study of Abiraterone Acetate in Patients With Advanced Prostate Cancer
NCT01217697 ·Status: APPROVED_FOR_MARKETING
-
Study to Assess Safety and Tolerability of AZD2171 After Multiple Doses in Patients With Advanced Prostate Cancer
NCT00502164 ·Status: COMPLETED ·Phase: PHASE1
-
Study of Abraxane Plus Hormonal Therapy as Initial Treatment of Unresectable or Metastatic Prostate Cancer
NCT00521781 ·Status: TERMINATED ·Phase: PHASE2
-
Study of AMG 509 in Participants With Metastatic Castration-Resistant Prostate Cancer
NCT04221542 ·Status: RECRUITING ·Phase: PHASE1
-
Study With [225Ac]Ac-FL-020 in mCRPC Participants
NCT06492122 ·Status: RECRUITING ·Phase: PHASE1
-
A Study of FT-7051 in Men With MCRPC
NCT04575766 ·Status: TERMINATED ·Phase: PHASE1
-
Study of Abiraterone Acetate Without Exogenous Glucocorticoids in Men With Castration-resistant Prostate Cancer
NCT02025010 ·Status: COMPLETED ·Phase: PHASE2
-
Study of Abiraterone Acetate in Subjects With Metastatic Castration Resistant Prostate Cancer
NCT04056754 ·Status: COMPLETED ·Phase: PHASE3
-
EMD 525797 in Subjects With Asymptomatic or Mildly Symptomatic Metastatic Castrate-resistant Prostate Cancer
NCT01360840 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of SHR3680 in Combination With SHR3162 in the Treatment of mCRPC
NCT04102124 ·Status: TERMINATED ·Phase: PHASE2
-
Cytoreductive Prostatectomy in Treating Patients With Newly Diagnosed, Metastatic Prostate Cancer
NCT02458716 ·Status: COMPLETED ·Phase: PHASE1
-
Abiraterone Acetate for Castrate Resistant Prostate Cancer
NCT01961843 ·Status: COMPLETED ·Phase: NA
-
Study of HPN424 in Patients With Advanced Prostate Cancer
NCT03577028 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
177Lu-PSMA-I&T for Metastatic Castration-Resistant Prostate Cancer
NCT05204927 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Phase I Trial of 225Ac-J591 in Patients With mCRPC
NCT03276572 ·Status: COMPLETED ·Phase: PHASE1
-
Trial of ARV-110 and Abiraterone in Participants With Metastatic Prostate Cancer
NCT05177042 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase 1a/1b Study to Evaluate the Safety of EZN-4176, in Adult Patients With Castration-Resistant Prostate Cancer
NCT01337518 ·Status: SUSPENDED ·Phase: PHASE1
-
BMTP-11 in Patients With Castrate-Resistant Prostate Cancer With Bone Mets
NCT00872157 ·Status: COMPLETED ·Phase: PHASE1