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Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

NCT05235165 · Status: RECRUITING · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 62

Last updated 2026-05-05

No results posted yet for this study

Summary

This phase III trial compares the effect of open thoracic surgery (thoracotomy) to thoracoscopic surgery (video-assisted thoracoscopic surgery or VATS) in treating patients with osteosarcoma that has spread to the lung (pulmonary metastases). Open thoracic surgery is a type of surgery done through a single larger incision (like a large cut) that goes between the ribs, opens up the chest, and removes the cancer. Thoracoscopy is a type of chest surgery where the doctor makes several small incisions and uses a small camera to help with removing the cancer. This trial is being done evaluate the two different surgery methods for patients with osteosarcoma that has spread to the lung to find out which is better.

Conditions

  • Metastatic Malignant Neoplasm in the Lung
  • Metastatic Osteosarcoma
  • Osteosarcoma

Interventions

PROCEDURE

Biospecimen Collection

Undergo collection of tissue and blood

PROCEDURE

Computed Tomography

Undergo CT

OTHER

Questionnaire Administration

Ancillary studies

PROCEDURE

Thoracoscopy

Undergo video-assisted thoracoscopic surgery or VATS

PROCEDURE

Thoracotomy

Undergo open thoracic surgery

Sponsors & Collaborators

  • National Cancer Institute (NCI)

    collaborator NIH

  • Children's Oncology Group

    lead NETWORK

Principal Investigators

  • John J Doski · Children's Oncology Group

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-04-01
Primary Completion
2031-03-31
Completion
2031-03-31
FDA Device
Yes

Countries

  • United States
  • Australia
  • Canada
  • New Zealand
  • Puerto Rico
  • Saudi Arabia

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05235165 on ClinicalTrials.gov