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Effect of Statin Therapy on Mortality in Patients With Ventilator Associated Pneumonia

NCT05230472 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 161

Last updated 2022-02-09

No results posted yet for this study

Summary

Statins with their powerful anti-inflammatory, immunomodulatory, and antioxidant properties make them candidate members to be used in the management of sepsis and different types of infections including pneumonia.

This study aims to determine whether adjunctive statin therapy decreased day- 28 mortality among ICU patients with ventilator-associated pneumonia (VAP) \& number of ventilator-free days (after successful weaning) between day 1 and both day 28.

Conditions

  • VAP - Ventilator Associated Pneumonia

Interventions

DRUG

Simvastatin

simvastatin 60 mg tab

Sponsors & Collaborators

  • Ain Shams University

    lead OTHER

Principal Investigators

  • YOUSEF FAWZY · Ain Shams University

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
29 Years
Max Age
71 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-01-01
Primary Completion
2021-12-20
Completion
2022-02-01

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05230472 on ClinicalTrials.gov