Interleukin-6 Antagonists in Critically-ill Covid-19 Patients
NCT05218369 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 30
Last updated 2023-04-20
Summary
The emerging SARS-COV2 virus has shed a new light on the cross-talks between the immune and the hemostatic system. In this study we aim to evaluate the dynamic change in coagulation caused by the modulation of the inflammatory response by interleukin-6 antagonist as assessed by viscoelastic methods in critically ill COVID-19 patients. Furthermore we try to draw attention to possible associations between the endothelial cell injury, inflammation and coagulation.
Conditions
- COVID-19
- Critical Illness
Interventions
- DRUG
-
IL6 Antagonist
Patients will receive IL-6 antagonist therapy at the consultant's discretion.
Sponsors & Collaborators
-
University of Pecs
lead OTHER
Eligibility
- Min Age
- 18 Years
- Max Age
- 100 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2022-02-06
- Primary Completion
- 2023-12-31
- Completion
- 2024-12-01
Countries
- Hungary
Study Locations
More Related Trials
-
Therapeutic Plasmapheresis in Critically Ill Adult Patients With COVID-19 Confirmed Diagnosis
NCT04480632 ·Status: UNKNOWN ·Phase: PHASE2
-
Immunoregulatory Therapy for 2019-nCoV
NCT04268537 ·Status: UNKNOWN ·Phase: PHASE2
-
Influence of In-line Microfilters on Systemic Inflammation in Adult Critically Ill Patients
NCT01534390 ·Status: COMPLETED ·Phase: PHASE2
-
Does GM-CSF Restore Neutrophil Phagocytosis in Critical Illness?
NCT01653665 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Effect of Montelukast Versus Co Enzyme in Sepsis
NCT05293132 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
Blood Markers for Identifying & Investigating Infection With COVID19 & Sepsis in Children.
NCT04904523 ·Status: UNKNOWN
-
GM-CSF Inhalation to Prevent ARDS in COVID-19 Pneumonia
NCT04569877 ·Status: COMPLETED ·Phase: PHASE2
-
Cytokine Hemadsorption in Covid 19 Patients With Bacterial Sepsis
NCT04920851 ·Status: UNKNOWN
-
Clinical Efficacy of Heparin and Tocilizumab in Patients With Severe COVID-19 Infection
NCT04600141 ·Status: COMPLETED ·Phase: PHASE3
-
Identification and Clinical Efficacy Analysis of Biomarkers in Sepsis Patients
NCT05911711 ·Status: UNKNOWN
-
Predictive Biomarkers of Secondary Aggravation in Covid-19 Suspect Patient
NCT04341792 ·Status: COMPLETED
-
Steroids and Unfractionated Heparin in Critically Ill Patients With Pneumonia From COVID-19 Infection
NCT04528888 ·Status: UNKNOWN ·Phase: PHASE3
-
ProAdrenomedullin Assessment of Multi-Organ Failure in COvid-19 Sepsis
NCT04522310 ·Status: COMPLETED
-
Identification of Cardiovascular and Molecular Prognostic Factors for the Mid- and Long-term Outcome of Sepsis
NCT03620409 ·Status: COMPLETED
-
Treatment of IL-6 and Its Receptor Antagonists in Children's Severe Sepsis.
NCT04850443 ·Status: WITHDRAWN
-
The Role of Emergency Neutrophils and Glycans in Postoperative and Septic Patients
NCT04117568 ·Status: TERMINATED
-
Monocyte Distribution Width (MDW): An Early Marker of Sepsis in Patients With Comorbidities
NCT06953154 ·Status: COMPLETED
-
Efficacy and Safety of Unfractionated Heparin on Severe Sepsis With Suspected Disseminated Intravascular Coagulation
NCT02654561 ·Status: RECRUITING ·Phase: PHASE3
-
Effect of Cytosorb on Blood Levels of Inflammatory Biomarkers of Sepsis.
NCT04226430 ·Status: COMPLETED
-
Early Procalcitonin Kinetics During Empirical Antibiotic Therapy in Critically Ill Patients
NCT02294695 ·Status: COMPLETED
-
Molecular Diagnosis and Risk Stratification of Sepsis
NCT01905033 ·Status: UNKNOWN
-
Recovery From Acute Immune Failure in Septic Shock by Immune Cell Extracorporeal Therapy - Observational Long-term Outcome Follow up
NCT06143137 ·Status: RECRUITING
-
Population Pharmacokinetics of Anti-infectives in Critically Ill Children
NCT02539407 ·Status: RECRUITING
-
Multicenter Symphony IL-6 Monitoring Sepsis ICU Study
NCT06181604 ·Status: COMPLETED
-
Statin for Immunomudulation in Sepsis
NCT00452608 ·Status: UNKNOWN ·Phase: PHASE2