MedTrace Logo

[18F]Fluoro-PEG-folate PET/CT Imaging in Epithelial Ovarian Cancer

NCT05215496 · Status: TERMINATED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 5

Last updated 2024-03-15

No results posted yet for this study

Summary

The pre-operative assessment of intra-abdominal tumor load in patients with epithelial ovarian cancer (EOC) remains unreliable with standard imaging modalities. The use of tumor targeted imaging, such as folate receptor (FR)-targeted positron emission tomography (PET) imaging could aid in the preoperative assessment of metastatic tumor load.

This study aims to evaluate the safety and tolerability, and pharmacokinetics of the \[18F\]fluoro-PEG-folate PET tracer and to assess the sensitivity and specificity of a \[18F\]fluoro-PEG-folate PET/CT scan for the preoperative detection of intra-abdominal metastatic lesions in patients with advanced stage epithelial ovarian cancer.

Conditions

  • Epithelial Ovarian Cancer

Interventions

DIAGNOSTIC_TEST

[18F]fluoro-PEG-folate PET/CT scan

A dynamic FR-targeted PET scan, a low-dose CT scan without contrast agents, and a static FR-targeted PET scan will be obtained

Sponsors & Collaborators

  • Amsterdam UMC, location VUmc

    collaborator OTHER

  • Centre for Human Drug Research, Netherlands

    collaborator OTHER

  • The Netherlands Cancer Institute

    collaborator OTHER

  • Lioe-Fee de Geus-Oei, MD PhD

    lead OTHER

Principal Investigators

  • Lioe-Fee de Geus-Oei, MD, PhD · LUMC

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
30 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-05-10
Primary Completion
2023-05-01
Completion
2023-05-01

Countries

  • Netherlands

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05215496 on ClinicalTrials.gov