Safety and Retention Rate of the JAK and TNF Inhibitors in Rheumatoid Arthritis: a Real-life Experience
NCT05182203 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 1732
Last updated 2023-02-22
Summary
This study aims to extract data from the Hong Kong Biologics Registry for retention rate of the JAK inhibitors in rheumatoid arthritis and review other adverse events by looking at the medical record retrospectively. These real life data are important as they cannot be provided by randomized controlled trials which are limited by the duration of observation and fixed protocols in research settings. Moreover, data will represent our local experience of the JAK inhibitors in Chinese patients with RA. The retention rate and adverse effects of the JAK inhibitors are compared with conventional TNF inhibitors.
Conditions
- Rheumatoid Arthritis
- Drug Use
Interventions
- DRUG
-
biologic/targeted therapy
TNF inhibitors or the JAK inhibitors
Sponsors & Collaborators
-
Tuen Mun Hospital
lead OTHER_GOV
Principal Investigators
-
Chi Chiu Mok, MD, FRCP · Tuen Mun Hospital
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2022-03-01
- Primary Completion
- 2022-09-01
- Completion
- 2022-10-01
Countries
- China
Study Locations
More Related Trials
-
The Safety and Efficacy of TLL-018 in Active Rheumatoid Arthritis
NCT05133297 ·Status: COMPLETED ·Phase: PHASE2
-
Efficacy and Safety of Abatacept Combined With JAK Inhibitor for Refractory Rheumatoid Arthritis
NCT05451615 ·Status: UNKNOWN ·Phase: PHASE3
-
An Global Comparative Observational Study of RoActemra/Actemra (Tocilizumab) in Patients With Rheumatoid Arthritis
NCT01543503 ·Status: COMPLETED
-
A Study to Evaluate the Efficacy and Safety of SHR0302 in Patients With Rheumatoid Arthritis
NCT04333771 ·Status: COMPLETED ·Phase: PHASE3
-
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Multiple Subcutaneous Injections of ABT-122 in Subjects With Rheumatoid Arthritis
NCT01853033 ·Status: COMPLETED ·Phase: PHASE1
-
Study to Assess the Safety and Tolerability of MEDI5117 in Rheumatoid Arthritis Patients
NCT01559103 ·Status: TERMINATED ·Phase: PHASE1
-
A Retrospective Chart Review on the Use of Biologics in Monotherapy for the Treatment of Patients With Rheumatoid Arthritis
NCT01640548 ·Status: COMPLETED
-
Efficacy and Safety Study of Jaktinib in Subjects With Active Ankylosing Spondylitis(AS)
NCT05861102 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
A Dose Range Finding Study of JNJ-38518168 in Patients With Active Rheumatoid Arthritis in Spite of Treatment With Methotrexate
NCT01679951 ·Status: TERMINATED ·Phase: PHASE2
-
A Study of Tocilizumab in Chinese Participants With Systemic Juvenile Idiopathic Arthritis (sJIA)
NCT03301883 ·Status: COMPLETED ·Phase: PHASE4
-
Pharmacokinetic and Safety Study With Adalimumab in Chinese Subjects With Mild Rheumatoid Arthritis
NCT00650156 ·Status: COMPLETED ·Phase: PHASE1
-
A Study With Upadacitinib (ABT-494) in Subjects From China and Selected Countries With Moderately to Severely Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Conventional Synthetic Disease-Modifying Anti-Rheumatic Drugs (csDMARDs)
NCT02955212 ·Status: COMPLETED ·Phase: PHASE3
-
The Efficacy and Safety of Tacrolimus in Refractory Rheumatoid Arthritis Patients for 6 Months and Long-term Treatment
NCT02837978 ·Status: COMPLETED ·Phase: PHASE4
-
Tolerance, Pharmacokinetics and Preliminary Efficacy of T0001 in RA (Rheumatoid Arthritis)
NCT02481180 ·Status: TERMINATED ·Phase: PHASE1
-
Methotrexate Combined With Tofacitinib in Rheumatoid Arthritis
NCT06301373 ·Status: RECRUITING ·Phase: NA
-
To Compare the Efficacy and Safety of Low-dose Glucocorticoids and Tofacitinib in Alleviating Moderate to High Disease Activity Rheumatoid Arthritis for 24 Weeks
NCT05606107 ·Status: UNKNOWN ·Phase: PHASE4
-
Clinical Comparative Study to Evaluate the Efficacy and Safety of Recombinant Anti-TNF-alpha Antibodies for Injection
NCT04178850 ·Status: UNKNOWN ·Phase: PHASE3
-
Tofacitinib (Xeljanz) Special Investigation for Rheumatoid Arthritis
NCT01932372 ·Status: COMPLETED
-
A Retrospective, Observational Chart Review of Biologics in Monotherapy Versus the Combination Biologic Plus Methotrexate in Patients With Rheumatoid Arthritis
NCT01866150 ·Status: COMPLETED
-
SWITCH Clinical Trial for Patients With Rheumatoid Arthritis Who Have Failed an Initial TNF-blocking Drug.
NCT01295151 ·Status: COMPLETED ·Phase: PHASE4
-
T Cells and TNF (Tumor Necrosis Factor): The Impact of TNF Blockade
NCT01060098 ·Status: COMPLETED
-
Assessment of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Subcutaneous Injections of GenSci120 in Healthy Adult Participants in China.
NCT07040930 ·Status: RECRUITING ·Phase: PHASE1
-
A Study of Tocilizumab (RoActemra/Actemra) in Monotherapy or in Combination With Methotrexate or Other Non-Biologic DMARDs in Participants With Active Rheumatoid Arthritis and an Inadequate Response to Current Non-Biologic DMARD Therapy or the First Anti-TNF Biologic Agent
NCT02046603 ·Status: COMPLETED ·Phase: PHASE3
-
An Observational Study in Rheumatoid Arthritis Patients Treated With RoActemra/Actemra (Tocilizumab)
NCT01565122 ·Status: COMPLETED
-
A Study of RoActemra/Actemra (Tocilizumab) in Combination With DMARDs Versus Current Best Practice DMARD Therapy in Patients With Rheumatoid Arthritis
NCT01251120 ·Status: TERMINATED ·Phase: PHASE4