Central Sensitization in Familial Mediterranean Fever (FMF)

Summary

Familial Mediterranean Fever (FMF) is an autosomal recessive inherited disease with a course of autoinflammation, which is characterized by the episodes of fever and serositis. Central sensitization (CS) is defined as increased response to normal or sub-threshold stimuli of central nervous system and its close relationship with many rheumatological diseases has been demonstrated in several studies. However, there are no data on the frequency of CS in FMF patients.

Conditions

• Familial Mediterranean Fever
• Central Sensitisation

Interventions

DIAGNOSTIC_TEST

Central Sensitization Inventory

Standardized questionnaire to determine the level of central sensitization

OTHER

Short form-36

Standardized questionnaire to investigate the quality of life in patients

OTHER

Pittsburgh Sleep Quality Index

Standardized questionnaire to investigate the sleep quality and disturbance

OTHER

Health assessment questionnaire

Standardized questionnaire used to detect the presence of disability

OTHER

Hospital anxiety and depression scale

Standardized questionnaire to investigate the depression and anxiety

DIAGNOSTIC_TEST

Fibromyalgia rapid screening tool

Standardized questionnaire to determine the presence of fibromyalgia

OTHER

Familial Mediterranean Fever Quality of life scale

Standardized questionnaire to investigate the quality of life in Familial Mediterranean Fever patients

Sponsors & Collaborators

• Marmara University

  lead OTHER

Principal Investigators

• Canan Sanal- Toprak, Asst.Prof · Marmara University

Eligibility

Min Age

18 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2021-06-01

Primary Completion

2022-04-10

Completion

2022-08-03

Countries

• Turkey (Türkiye)

Study Locations