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Diabetic Foot Ulcer (DFU) Biofilm Infection and Recurrence

NCT05172089 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 405

Last updated 2026-03-18

No results posted yet for this study

Summary

This work is based on DFU patients, seeks to conduct a fully powered clinical study testing i) If DFU with a history of biofilm infection closes with deficient barrier function. ii) whether such functionally deficient wound closure, manifested as high TEWL, is associated with greater wound recurrence. The primary parent study will also address molecular mechanisms implicated in biofilm-induced loss of skin epithelial barrier integrity in DFU patients.

Conditions

  • Chronic Wounds
  • Biofilm Infection
  • Trans-epidermal Water Loss (TEWL)
  • Diabetic Foot
  • Diabetic Foot Infection

Sponsors & Collaborators

  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    collaborator NIH

  • University of Arizona

    collaborator OTHER

  • University of Pittsburgh

    lead OTHER

Principal Investigators

  • Chandan K Sen, PhD · University of Pittsburgh

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-04-02
Primary Completion
2028-06-27
Completion
2029-06-27

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05172089 on ClinicalTrials.gov