Trial Outcomes & Findings for Michigan Genetic Hereditary Testing (MiGHT) (NCT NCT05162846)
NCT ID: NCT05162846
Last Updated: 2026-08-18
Results Overview
The primary outcome is completion of genetic testing (yes/no) at 6 months after randomization by patient self-report.
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
793 participants
Primary outcome timeframe
6 months after enrollment/randomization
Results posted on
2026-08-18
Participant Flow
Participant milestones
| Measure |
Arm 1 - Usual Care (UC)
Participants are provided with a link to the Michigan Department of Health and Human Services (MDHHS) informational website and are instructed to follow up with their oncology provider about genetic testing.
Publicly available genetic testing resources: Participants may view the publicly available Michigan Department of Health and Human Services (MDHHS) website as they wish.
|
Arm 2 - Virtual Genetics Navigator (Digital Intervention)
Participants receive access to an online genetics tool, the virtual genetics navigator, to help learn why and how to seek out genetic testing for hereditary cancer syndromes.
Virtual genetics navigator: A mobile-optimized website/online genetic tool developed by investigators from the University of Michigan's Center for Health Communications Research (CHCR).
|
Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching)
Participants receive up to 2 phone calls from trained genetics health coaches who provide information about genetic testing and use motivational interviewing to encourage participants to seek out clinical genetic testing.
Motivational interviewing (MI): At least 2 phone calls delivered by trained genetic health coaches using motivational interviewing and providing genetic testing information.
|
|---|---|---|---|
|
Overall Study
STARTED
|
267
|
265
|
261
|
|
Overall Study
COMPLETED
|
267
|
265
|
261
|
|
Overall Study
NOT COMPLETED
|
0
|
0
|
0
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Not every participant responded to this question
Baseline characteristics by cohort
| Measure |
Arm 1 - Usual Care (UC)
n=267 Participants
Participants are provided with a link to the Michigan Department of Health and Human Services (MDHHS) informational website and are instructed to follow up with their oncology provider about genetic testing.
Publicly available genetic testing resources: Participants may view the publicly available Michigan Department of Health and Human Services (MDHHS) website as they wish.
|
Arm 2 - Virtual Genetics Navigator (Digital Intervention)
n=265 Participants
Participants receive access to an online genetics tool, the virtual genetics navigator, to help learn why and how to seek out genetic testing for hereditary cancer syndromes.
Virtual genetics navigator: A mobile-optimized website/online genetic tool developed by investigators from the University of Michigan's Center for Health Communications Research (CHCR).
|
Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching)
n=261 Participants
Participants receive up to 2 phone calls from trained genetics health coaches who provide information about genetic testing and use motivational interviewing to encourage participants to seek out clinical genetic testing.
Motivational interviewing (MI): At least 2 phone calls delivered by trained genetic health coaches using motivational interviewing and providing genetic testing information.
|
Total
n=793 Participants
Total of all reporting groups
|
|---|---|---|---|---|
|
Age, Continuous
|
64 years
n=267 Participants
|
62 years
n=265 Participants
|
64 years
n=261 Participants
|
64 years
n=793 Participants
|
|
Sex/Gender, Customized
Female
|
165 Participants
n=264 Participants • Not every participant responded to this question
|
143 Participants
n=264 Participants • Not every participant responded to this question
|
150 Participants
n=258 Participants • Not every participant responded to this question
|
458 Participants
n=786 Participants • Not every participant responded to this question
|
|
Sex/Gender, Customized
Male
|
98 Participants
n=264 Participants • Not every participant responded to this question
|
116 Participants
n=264 Participants • Not every participant responded to this question
|
106 Participants
n=258 Participants • Not every participant responded to this question
|
320 Participants
n=786 Participants • Not every participant responded to this question
|
|
Sex/Gender, Customized
Other
|
1 Participants
n=264 Participants • Not every participant responded to this question
|
5 Participants
n=264 Participants • Not every participant responded to this question
|
2 Participants
n=258 Participants • Not every participant responded to this question
|
8 Participants
n=786 Participants • Not every participant responded to this question
|
|
Ethnicity (NIH/OMB)
Hispanic or Latino
|
8 Participants
n=257 Participants • not every participant responded to each demographic question
|
9 Participants
n=260 Participants • not every participant responded to each demographic question
|
12 Participants
n=253 Participants • not every participant responded to each demographic question
|
29 Participants
n=770 Participants • not every participant responded to each demographic question
|
|
Ethnicity (NIH/OMB)
Not Hispanic or Latino
|
249 Participants
n=257 Participants • not every participant responded to each demographic question
|
251 Participants
n=260 Participants • not every participant responded to each demographic question
|
241 Participants
n=253 Participants • not every participant responded to each demographic question
|
741 Participants
n=770 Participants • not every participant responded to each demographic question
|
|
Ethnicity (NIH/OMB)
Unknown or Not Reported
|
0 Participants
n=257 Participants • not every participant responded to each demographic question
|
0 Participants
n=260 Participants • not every participant responded to each demographic question
|
0 Participants
n=253 Participants • not every participant responded to each demographic question
|
0 Participants
n=770 Participants • not every participant responded to each demographic question
|
|
Race (NIH/OMB)
American Indian or Alaska Native
|
0 Participants
n=257 Participants • not every participant responded to each demographic question
|
0 Participants
n=260 Participants • not every participant responded to each demographic question
|
0 Participants
n=255 Participants • not every participant responded to each demographic question
|
0 Participants
n=772 Participants • not every participant responded to each demographic question
|
|
Race (NIH/OMB)
Asian
|
0 Participants
n=257 Participants • not every participant responded to each demographic question
|
0 Participants
n=260 Participants • not every participant responded to each demographic question
|
0 Participants
n=255 Participants • not every participant responded to each demographic question
|
0 Participants
n=772 Participants • not every participant responded to each demographic question
|
|
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
|
0 Participants
n=257 Participants • not every participant responded to each demographic question
|
0 Participants
n=260 Participants • not every participant responded to each demographic question
|
0 Participants
n=255 Participants • not every participant responded to each demographic question
|
0 Participants
n=772 Participants • not every participant responded to each demographic question
|
|
Race (NIH/OMB)
Black or African American
|
9 Participants
n=257 Participants • not every participant responded to each demographic question
|
14 Participants
n=260 Participants • not every participant responded to each demographic question
|
13 Participants
n=255 Participants • not every participant responded to each demographic question
|
36 Participants
n=772 Participants • not every participant responded to each demographic question
|
|
Race (NIH/OMB)
White
|
222 Participants
n=257 Participants • not every participant responded to each demographic question
|
221 Participants
n=260 Participants • not every participant responded to each demographic question
|
222 Participants
n=255 Participants • not every participant responded to each demographic question
|
665 Participants
n=772 Participants • not every participant responded to each demographic question
|
|
Race (NIH/OMB)
More than one race
|
0 Participants
n=257 Participants • not every participant responded to each demographic question
|
0 Participants
n=260 Participants • not every participant responded to each demographic question
|
0 Participants
n=255 Participants • not every participant responded to each demographic question
|
0 Participants
n=772 Participants • not every participant responded to each demographic question
|
|
Race (NIH/OMB)
Unknown or Not Reported
|
26 Participants
n=257 Participants • not every participant responded to each demographic question
|
25 Participants
n=260 Participants • not every participant responded to each demographic question
|
20 Participants
n=255 Participants • not every participant responded to each demographic question
|
71 Participants
n=772 Participants • not every participant responded to each demographic question
|
|
Region of Enrollment
United States
|
267 participants
n=267 Participants
|
265 participants
n=265 Participants
|
261 participants
n=261 Participants
|
793 participants
n=793 Participants
|
PRIMARY outcome
Timeframe: 6 months after enrollment/randomizationThe primary outcome is completion of genetic testing (yes/no) at 6 months after randomization by patient self-report.
Outcome measures
| Measure |
Arm 1 - Usual Care (UC)
n=230 Participants
Participants are provided with a link to the Michigan Department of Health and Human Services (MDHHS) informational website and are instructed to follow up with their oncology provider about genetic testing.
Publicly available genetic testing resources: Participants may view the publicly available Michigan Department of Health and Human Services (MDHHS) website as they wish.
|
Arm 2 - Virtual Genetics Navigator (Digital Intervention)
n=205 Participants
Participants receive access to an online genetics tool, the virtual genetics navigator, to help learn why and how to seek out genetic testing for hereditary cancer syndromes.
Virtual genetics navigator: A mobile-optimized website/online genetic tool developed by investigators from the University of Michigan's Center for Health Communications Research (CHCR).
|
Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching)
n=201 Participants
Participants receive up to 2 phone calls from trained genetics health coaches who provide information about genetic testing and use motivational interviewing to encourage participants to seek out clinical genetic testing.
Motivational interviewing (MI): At least 2 phone calls delivered by trained genetic health coaches using motivational interviewing and providing genetic testing information.
|
|---|---|---|---|
|
Percentage of Participants Who Complete Clinical Genetic Testing at Six Months After Randomization
|
5 Participants
|
15 Participants
|
11 Participants
|
SECONDARY outcome
Timeframe: 6 months and 12 months after enrollment/randomizationPopulation: Not all participants responded to each item
Participants who have completed genetic testing (before the 6- or 12-month time point for this survey) will be asked to respond to this 7-item, study-specific survey, developed by the investigators to assess the importance of specific barriers that were identified in a previous, observational study. Each item is scored on a scale from 1-5 (1=not at all; 5=extremely). The mean score for each question, across all participants who completed genetic testing, will be calculated in order to rank the barriers in importance. A higher mean score indicates greater importance of that specific barrier.
Outcome measures
| Measure |
Arm 1 - Usual Care (UC)
n=27 Participants
Participants are provided with a link to the Michigan Department of Health and Human Services (MDHHS) informational website and are instructed to follow up with their oncology provider about genetic testing.
Publicly available genetic testing resources: Participants may view the publicly available Michigan Department of Health and Human Services (MDHHS) website as they wish.
|
Arm 2 - Virtual Genetics Navigator (Digital Intervention)
n=42 Participants
Participants receive access to an online genetics tool, the virtual genetics navigator, to help learn why and how to seek out genetic testing for hereditary cancer syndromes.
Virtual genetics navigator: A mobile-optimized website/online genetic tool developed by investigators from the University of Michigan's Center for Health Communications Research (CHCR).
|
Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching)
n=32 Participants
Participants receive up to 2 phone calls from trained genetics health coaches who provide information about genetic testing and use motivational interviewing to encourage participants to seek out clinical genetic testing.
Motivational interviewing (MI): At least 2 phone calls delivered by trained genetic health coaches using motivational interviewing and providing genetic testing information.
|
|---|---|---|---|
|
Barriers to Genetic Testing, for Participants Who Completed Genetic Testing
Q1: Convincing my doctor I needed testing- 12 Month Survey
|
1.0 score on a scale
Standard Deviation 0
|
1.38 score on a scale
Standard Deviation 1.06
|
1.13 score on a scale
Standard Deviation 0.56
|
|
Barriers to Genetic Testing, for Participants Who Completed Genetic Testing
Q2: Finding out how to get testing- 12 Month Survey
|
1.36 score on a scale
Standard Deviation 0.63
|
1.33 score on a scale
Standard Deviation 0.76
|
1.13 score on a scale
Standard Deviation 0.56
|
|
Barriers to Genetic Testing, for Participants Who Completed Genetic Testing
Q3: Finding time to get tested- 6 Month Survey
|
1.0 score on a scale
Standard Deviation 0
|
1.14 score on a scale
Standard Deviation 0.53
|
1.0 score on a scale
Standard Deviation 0
|
|
Barriers to Genetic Testing, for Participants Who Completed Genetic Testing
Q3: Finding time to get tested- 12 Month Survey
|
1.40 score on a scale
Standard Deviation 0.74
|
1.25 score on a scale
Standard Deviation 0.61
|
1.06 score on a scale
Standard Deviation 0.25
|
|
Barriers to Genetic Testing, for Participants Who Completed Genetic Testing
Q4: Figuring out how to pay for testing- 6 Month Survey
|
2.80 score on a scale
Standard Deviation 2.05
|
1.64 score on a scale
Standard Deviation 1.08
|
1.55 score on a scale
Standard Deviation 0.82
|
|
Barriers to Genetic Testing, for Participants Who Completed Genetic Testing
Q4: Figuring out how to pay for testing- 12 Month Survey
|
1.40 score on a scale
Standard Deviation 1.12
|
1.42 score on a scale
Standard Deviation 0.72
|
1.39 score on a scale
Standard Deviation 0.95
|
|
Barriers to Genetic Testing, for Participants Who Completed Genetic Testing
Q5: Getting ready emotionally to receive results- 6 Month Survey
|
1.60 score on a scale
Standard Deviation 0.55
|
1.29 score on a scale
Standard Deviation 0.73
|
1.55 score on a scale
Standard Deviation 0.82
|
|
Barriers to Genetic Testing, for Participants Who Completed Genetic Testing
Q6: Understanding why testing was important for me- 6 Month Survey
|
1.80 score on a scale
Standard Deviation 0.84
|
1.07 score on a scale
Standard Deviation 0.27
|
1.82 score on a scale
Standard Deviation 1.47
|
|
Barriers to Genetic Testing, for Participants Who Completed Genetic Testing
Q6: Understanding why testing was important for me- 12 Month Survey
|
1.73 score on a scale
Standard Deviation 1.28
|
1.79 score on a scale
Standard Deviation 1.25
|
1.39 score on a scale
Standard Deviation 0.99
|
|
Barriers to Genetic Testing, for Participants Who Completed Genetic Testing
Q7: Understanding my results- 6 Month Survey
|
2.00 score on a scale
Standard Deviation 0
|
1.30 score on a scale
Standard Deviation 0.67
|
2.22 score on a scale
Standard Deviation 1.30
|
|
Barriers to Genetic Testing, for Participants Who Completed Genetic Testing
Q7: Understanding my results- 12 Month Survey
|
2.43 score on a scale
Standard Deviation 1.40
|
1.70 score on a scale
Standard Deviation 1.11
|
1.70 score on a scale
Standard Deviation 1.10
|
|
Barriers to Genetic Testing, for Participants Who Completed Genetic Testing
Q5: Getting ready emotionally to receive results- 12 Month Survey
|
2.07 score on a scale
Standard Deviation 1.10
|
1.83 score on a scale
Standard Deviation 1.20
|
1.58 score on a scale
Standard Deviation 1.06
|
|
Barriers to Genetic Testing, for Participants Who Completed Genetic Testing
Q1: Convincing my doctor I needed testing- 6 Month Survey
|
1.20 score on a scale
Standard Deviation 0.45
|
1.57 score on a scale
Standard Deviation 1.16
|
1.0 score on a scale
Standard Deviation 0
|
|
Barriers to Genetic Testing, for Participants Who Completed Genetic Testing
Q2: Finding out how to get testing- 6 Month Survey
|
1.0 score on a scale
Standard Deviation 0
|
1.57 score on a scale
Standard Deviation 1.02
|
1.09 score on a scale
Standard Deviation 0.30
|
SECONDARY outcome
Timeframe: 6 months and 12 months after enrollment/randomizationPopulation: Not all participants responded to each item
Participants who have not yet completed genetic testing (before the 6- or 12-month time point for this survey) will be asked to respond to this 23-item, study-specific survey, developed by the investigators to assess the importance of specific barriers that were identified in a previous, observational study. Each item is scored on a scale from 1-5 (1=not at all, 5=strongly agree). The mean score for each question, across all participants who have not yet completed genetic testing, will be calculated in order to rank the barriers in importance. A higher mean score indicates greater importance of that specific barrier.
Outcome measures
| Measure |
Arm 1 - Usual Care (UC)
n=218 Participants
Participants are provided with a link to the Michigan Department of Health and Human Services (MDHHS) informational website and are instructed to follow up with their oncology provider about genetic testing.
Publicly available genetic testing resources: Participants may view the publicly available Michigan Department of Health and Human Services (MDHHS) website as they wish.
|
Arm 2 - Virtual Genetics Navigator (Digital Intervention)
n=185 Participants
Participants receive access to an online genetics tool, the virtual genetics navigator, to help learn why and how to seek out genetic testing for hereditary cancer syndromes.
Virtual genetics navigator: A mobile-optimized website/online genetic tool developed by investigators from the University of Michigan's Center for Health Communications Research (CHCR).
|
Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching)
n=189 Participants
Participants receive up to 2 phone calls from trained genetics health coaches who provide information about genetic testing and use motivational interviewing to encourage participants to seek out clinical genetic testing.
Motivational interviewing (MI): At least 2 phone calls delivered by trained genetic health coaches using motivational interviewing and providing genetic testing information.
|
|---|---|---|---|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q7: I don't have time to get genetic testing- 6 Month Survey
|
1.72 score on a scale
Standard Deviation 0.74
|
1.74 score on a scale
Standard Deviation 0.80
|
1.75 score on a scale
Standard Deviation 0.85
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q7: I don't have time to get genetic testing- 12 Month Survey
|
1.96 score on a scale
Standard Deviation 0.88
|
2.12 score on a scale
Standard Deviation 0.98
|
2.26 score on a scale
Standard Deviation 1.00
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q17: Knowing my genetic status would not change my cancer treatment- 6 months
|
3.09 score on a scale
Standard Deviation 1.33
|
2.88 score on a scale
Standard Deviation 1.29
|
2.97 score on a scale
Standard Deviation 1.30
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q17: Knowing my genetic status would not change my cancer treatment- 12 months
|
2.88 score on a scale
Standard Deviation 1.24
|
3.07 score on a scale
Standard Deviation 1.23
|
3.01 score on a scale
Standard Deviation 1.16
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q18: Knowing my genetic status would not change my cancer follow-up care and monitoring- 6 months
|
3.00 score on a scale
Standard Deviation 1.42
|
2.89 score on a scale
Standard Deviation 1.44
|
3.06 score on a scale
Standard Deviation 1.43
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q18: Knowing my genetic status would not change my cancer follow-up care and monitoring- 12 months
|
2.90 score on a scale
Standard Deviation 1.27
|
3.07 score on a scale
Standard Deviation 1.26
|
2.90 score on a scale
Standard Deviation 1.21
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q19- My genetic status would not change what I can do to prevent getting another cancer- 6 months
|
2.79 score on a scale
Standard Deviation 1.44
|
2.84 score on a scale
Standard Deviation 1.40
|
2.87 score on a scale
Standard Deviation 1.40
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q1: Getting genetic testing would cost me too much money- 6 Month Survey
|
2.88 score on a scale
Standard Deviation 1.04
|
2.86 score on a scale
Standard Deviation 1.16
|
2.85 score on a scale
Standard Deviation 1.01
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q1: Getting genetic testing would cost me too much money- 12 Month Survey
|
2.82 score on a scale
Standard Deviation 1.05
|
2.90 score on a scale
Standard Deviation 1.24
|
2.93 score on a scale
Standard Deviation 1.13
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q2: I worry that my health insurance would not cover the cost of genetic testing- 6 Month Survey
|
3.28 score on a scale
Standard Deviation 1.19
|
3.28 score on a scale
Standard Deviation 1.30
|
3.31 score on a scale
Standard Deviation 1.15
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q2: I worry that my health insurance would not cover the cost of genetic testing- 12 Month Survey
|
3.30 score on a scale
Standard Deviation 1.23
|
3.35 score on a scale
Standard Deviation 1.21
|
3.25 score on a scale
Standard Deviation 1.25
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q3: I would worry about how genetic testing would affect my health insurance rates- 6 Month Survey
|
2.82 score on a scale
Standard Deviation 1.29
|
2.77 score on a scale
Standard Deviation 1.32
|
3.01 score on a scale
Standard Deviation 1.25
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q3: I would worry about how genetic testing would affect my health insurance rates- 12 Month Survey
|
2.84 score on a scale
Standard Deviation 1.28
|
2.93 score on a scale
Standard Deviation 1.25
|
2.92 score on a scale
Standard Deviation 1.26
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q10: I am too overwhelmed to think about genetic testing right now - 12 Months
|
2.15 score on a scale
Standard Deviation 1.08
|
2.26 score on a scale
Standard Deviation 1.16
|
2.46 score on a scale
Standard Deviation 1.14
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q6: If found to carry an altered gene, I worry about who would have access to results- 12 Months
|
2.36 score on a scale
Standard Deviation 1.23
|
2.58 score on a scale
Standard Deviation 1.25
|
2.52 score on a scale
Standard Deviation 1.21
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q12: If I were found to carry an altered gene, I would feel hopeless/sad- 6 months
|
2.44 score on a scale
Standard Deviation 1.03
|
2.43 score on a scale
Standard Deviation 1.03
|
2.55 score on a scale
Standard Deviation 1.03
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q16: Knowing that I carry an altered gene would make me feel defective- 6 months
|
1.86 score on a scale
Standard Deviation 0.90
|
1.88 score on a scale
Standard Deviation 0.87
|
1.99 score on a scale
Standard Deviation 0.91
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q11: If I were found to carry an altered gene, I would feel angry- 6 months
|
2.30 score on a scale
Standard Deviation 1.05
|
2.30 score on a scale
Standard Deviation 0.95
|
2.45 score on a scale
Standard Deviation 1.02
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q21: I'm not sure if the test is accurate- 12 months
|
2.29 score on a scale
Standard Deviation 0.83
|
2.10 score on a scale
Standard Deviation 0.82
|
2.27 score on a scale
Standard Deviation 0.79
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q4: If I were found to carry an altered gene, I worry it would affect my life insurance- 6 Month
|
2.53 score on a scale
Standard Deviation 1.24
|
2.64 score on a scale
Standard Deviation 1.31
|
2.74 score on a scale
Standard Deviation 1.18
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q15: I would feel anxious while waiting for my results- 12 months
|
3.03 score on a scale
Standard Deviation 1.16
|
3.02 score on a scale
Standard Deviation 1.07
|
3.06 score on a scale
Standard Deviation 1.11
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q16: Knowing that I carry an altered gene would make me feel defective- 12 months
|
2.07 score on a scale
Standard Deviation 0.91
|
2.15 score on a scale
Standard Deviation 0.93
|
2.17 score on a scale
Standard Deviation 0.98
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q4: If I were found to carry an altered gene, I worry it would affect my life insurance- 12 Month
|
2.58 score on a scale
Standard Deviation 1.24
|
2.52 score on a scale
Standard Deviation 1.21
|
2.70 score on a scale
Standard Deviation 1.24
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q5: If found to carry an altered gene, I worry it would affect my insurance eligibility- 6 Month
|
2.87 score on a scale
Standard Deviation 1.26
|
2.72 score on a scale
Standard Deviation 1.29
|
2.98 score on a scale
Standard Deviation 1.28
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q5: If found to carry an altered gene, I worry it would affect my insurance eligibility- 12 Month
|
2.93 score on a scale
Standard Deviation 1.26
|
2.91 score on a scale
Standard Deviation 1.27
|
2.96 score on a scale
Standard Deviation 1.29
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q6: If found to carry an altered gene, I worry about who would have access to results- 6 Months
|
2.47 score on a scale
Standard Deviation 125
|
2.23 score on a scale
Standard Deviation 1.15
|
2.45 score on a scale
Standard Deviation 1.20
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q8: Genetic testing would not help me deal with fears about having cancer again- 6 month survey
|
2.41 score on a scale
Standard Deviation 1.05
|
2.30 score on a scale
Standard Deviation 0.99
|
2.47 score on a scale
Standard Deviation 1.04
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q8: Genetic testing would not help me deal with fears about having cancer again- 12 month survey
|
2.68 score on a scale
Standard Deviation 1.11
|
2.67 score on a scale
Standard Deviation 1.16
|
2.74 score on a scale
Standard Deviation 1.10
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q9: I have too much going on with my current cancer diagnosis to think about testing- 6 month
|
1.90 score on a scale
Standard Deviation 0.87
|
1.81 score on a scale
Standard Deviation 0.79
|
1.81 score on a scale
Standard Deviation 0.83
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q9: I have too much going on with my current cancer diagnosis to think about testing- 12 month
|
2.10 score on a scale
Standard Deviation 0.99
|
2.25 score on a scale
Standard Deviation 1.03
|
2.51 score on a scale
Standard Deviation 1.13
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q10: I am too overwhelmed to think about genetic testing right now - 6 Months
|
1.79 score on a scale
Standard Deviation 0.82
|
1.78 score on a scale
Standard Deviation 0.83
|
1.75 score on a scale
Standard Deviation 0.77
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q11: If I were found to carry an altered gene, I would feel angry- 12 months
|
2.51 score on a scale
Standard Deviation 1.01
|
2.45 score on a scale
Standard Deviation 1.00
|
2.51 score on a scale
Standard Deviation 0.96
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q12: If I were found to carry an altered gene, I would feel hopeless/sad- 12 months
|
2.62 score on a scale
Standard Deviation 1.03
|
2.67 score on a scale
Standard Deviation 1.08
|
2.70 score on a scale
Standard Deviation 1.02
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q13: If I were found to carry an altered gene, I would feel guilty about passing it on- 6 Months
|
2.83 score on a scale
Standard Deviation 1.21
|
2.66 score on a scale
Standard Deviation 1.28
|
2.80 score on a scale
Standard Deviation 1.17
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q13: If I were found to carry an altered gene, I would feel guilty about passing it on- 12 Months
|
2.87 score on a scale
Standard Deviation 1.14
|
2.80 score on a scale
Standard Deviation 1.24
|
2.91 score on a scale
Standard Deviation 1.20
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q14: If I were found to carry an altered gene, I would feel anxious- 6 Months
|
3.20 score on a scale
Standard Deviation 1.15
|
3.13 score on a scale
Standard Deviation 1.13
|
3.28 score on a scale
Standard Deviation 1.12
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q14: If I were found to carry an altered gene, I would feel anxious- 12 Months
|
3.35 score on a scale
Standard Deviation 1.01
|
3.23 score on a scale
Standard Deviation 1.09
|
3.37 score on a scale
Standard Deviation 1.03
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q15: I would feel anxious while waiting for my results- 6 months
|
2.97 score on a scale
Standard Deviation 1.16
|
2.79 score on a scale
Standard Deviation 1.13
|
2.93 score on a scale
Standard Deviation 1.08
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q19- My genetic status would not change what I can do to prevent getting another cancer- 12 months
|
2.79 score on a scale
Standard Deviation 1.20
|
3.06 score on a scale
Standard Deviation 1.19
|
2.89 score on a scale
Standard Deviation 1.17
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q20: I don't know how genetic testing benefits me- 6 months
|
2.41 score on a scale
Standard Deviation 1.08
|
2.46 score on a scale
Standard Deviation 1.02
|
2.35 score on a scale
Standard Deviation 0.98
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q20: I don't know how genetic testing benefits me- 12 months
|
2.47 score on a scale
Standard Deviation 0.95
|
2.31 score on a scale
Standard Deviation 0.97
|
2.47 score on a scale
Standard Deviation 1.01
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q21: I'm not sure if the test is accurate- 6 months
|
2.27 score on a scale
Standard Deviation 0.84
|
2.19 score on a scale
Standard Deviation 0.83
|
2.33 score on a scale
Standard Deviation 0.89
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q22: I don't know how to get genetic testing- 6 months
|
3.11 score on a scale
Standard Deviation 1.08
|
3.16 score on a scale
Standard Deviation 1.10
|
3.13 score on a scale
Standard Deviation 1.05
|
|
Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q22: I don't know how to get genetic testing- 12 months
|
2.99 score on a scale
Standard Deviation 1.09
|
2.48 score on a scale
Standard Deviation 1.10
|
2.65 score on a scale
Standard Deviation 1.13
|
SECONDARY outcome
Timeframe: 6 months and 12 months after enrollment/randomizationPopulation: Not all participants responded to each item
Participants who have completed genetic testing (before the 6- or 12-month time point for this survey) will be asked to respond to this 5-item, study-specific survey, developed by the investigators to assess the importance of specific motivators for future testing. Each item is scored on a scale from 1-5 (1=not at all; 5=extremely). The mean score for each question, across all participants who completed genetic testing, will be calculated in order to rank the motivators in importance. A higher mean score indicates greater importance of that specific motivator.
Outcome measures
| Measure |
Arm 1 - Usual Care (UC)
n=15 Participants
Participants are provided with a link to the Michigan Department of Health and Human Services (MDHHS) informational website and are instructed to follow up with their oncology provider about genetic testing.
Publicly available genetic testing resources: Participants may view the publicly available Michigan Department of Health and Human Services (MDHHS) website as they wish.
|
Arm 2 - Virtual Genetics Navigator (Digital Intervention)
n=24 Participants
Participants receive access to an online genetics tool, the virtual genetics navigator, to help learn why and how to seek out genetic testing for hereditary cancer syndromes.
Virtual genetics navigator: A mobile-optimized website/online genetic tool developed by investigators from the University of Michigan's Center for Health Communications Research (CHCR).
|
Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching)
n=31 Participants
Participants receive up to 2 phone calls from trained genetics health coaches who provide information about genetic testing and use motivational interviewing to encourage participants to seek out clinical genetic testing.
Motivational interviewing (MI): At least 2 phone calls delivered by trained genetic health coaches using motivational interviewing and providing genetic testing information.
|
|---|---|---|---|
|
Motivators of Genetic Testing, for Participants Who Completed Genetic Testing
Q1: Knowing my genetic status could help me plan my treatment- 12 Month Survey
|
3.27 score on a scale
Standard Deviation 1.68
|
3.62 score on a scale
Standard Deviation 1.53
|
3.58 score on a scale
Standard Deviation 1.59
|
|
Motivators of Genetic Testing, for Participants Who Completed Genetic Testing
Q2: Knowing my genetic status would impact my cancer screening- 6 months
|
3.40 score on a scale
Standard Deviation 1.52
|
2.86 score on a scale
Standard Deviation 1.51
|
3.45 score on a scale
Standard Deviation 1.57
|
|
Motivators of Genetic Testing, for Participants Who Completed Genetic Testing
Q5: A healthcare provider recommended it- 12 months
|
3.60 score on a scale
Standard Deviation 1.45
|
2.83 score on a scale
Standard Deviation 1.43
|
3.58 score on a scale
Standard Deviation 1.52
|
|
Motivators of Genetic Testing, for Participants Who Completed Genetic Testing
Q2: Knowing my genetic status would impact my cancer screening- 12 months
|
4.00 score on a scale
Standard Deviation 1.36
|
3.71 score on a scale
Standard Deviation 1.57
|
3.55 score on a scale
Standard Deviation 1.46
|
|
Motivators of Genetic Testing, for Participants Who Completed Genetic Testing
Q3: I would be relieved to know my risk for hereditary cancer- 6 months
|
3.80 score on a scale
Standard Deviation 0.84
|
4.14 score on a scale
Standard Deviation 1.03
|
4.18 score on a scale
Standard Deviation 0.98
|
|
Motivators of Genetic Testing, for Participants Who Completed Genetic Testing
Q3: I would be relieved to know my risk for hereditary cancer- 12 months
|
4.00 score on a scale
Standard Deviation 1.51
|
4.38 score on a scale
Standard Deviation 1.10
|
4.16 score on a scale
Standard Deviation 1.29
|
|
Motivators of Genetic Testing, for Participants Who Completed Genetic Testing
Q4: I wanted to make sure my family had information that could affect their health- 6 months
|
4.40 score on a scale
Standard Deviation 0.89
|
4.36 score on a scale
Standard Deviation 0.84
|
4.45 score on a scale
Standard Deviation 0.93
|
|
Motivators of Genetic Testing, for Participants Who Completed Genetic Testing
Q4: I wanted to make sure my family had information that could affect their health- 12 months
|
4.00 score on a scale
Standard Deviation 1.20
|
4.58 score on a scale
Standard Deviation 0.72
|
4.39 score on a scale
Standard Deviation 1.12
|
|
Motivators of Genetic Testing, for Participants Who Completed Genetic Testing
Q5: A healthcare provider recommended it- 6 months
|
3.80 score on a scale
Standard Deviation 1.30
|
2.36 score on a scale
Standard Deviation 1.34
|
3.09 score on a scale
Standard Deviation 1.64
|
|
Motivators of Genetic Testing, for Participants Who Completed Genetic Testing
Q1: Knowing my genetic status could help me plan my treatment- 6 Month Survey
|
2.50 score on a scale
Standard Deviation 2.12
|
3.92 score on a scale
Standard Deviation 1.24
|
3.89 score on a scale
Standard Deviation 1.69
|
SECONDARY outcome
Timeframe: 6 months and 12 months after enrollment/randomizationPopulation: Not all participants responded to each item
Participants who have not yet completed genetic testing (before the 6- or 12-month time point for this survey) will be asked to respond to this 5-item, study-specific survey, developed by the investigators to assess the importance of specific motivators for future testing. Each item is scored on a scale from 1-5 (1=not at all, 5=strongly agree). The mean score for each question, across all participants who have not yet completed genetic testing, will be calculated in order to rank the motivators in importance. A higher mean score indicates greater importance of that specific motivator.
Outcome measures
| Measure |
Arm 1 - Usual Care (UC)
n=220 Participants
Participants are provided with a link to the Michigan Department of Health and Human Services (MDHHS) informational website and are instructed to follow up with their oncology provider about genetic testing.
Publicly available genetic testing resources: Participants may view the publicly available Michigan Department of Health and Human Services (MDHHS) website as they wish.
|
Arm 2 - Virtual Genetics Navigator (Digital Intervention)
n=189 Participants
Participants receive access to an online genetics tool, the virtual genetics navigator, to help learn why and how to seek out genetic testing for hereditary cancer syndromes.
Virtual genetics navigator: A mobile-optimized website/online genetic tool developed by investigators from the University of Michigan's Center for Health Communications Research (CHCR).
|
Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching)
n=182 Participants
Participants receive up to 2 phone calls from trained genetics health coaches who provide information about genetic testing and use motivational interviewing to encourage participants to seek out clinical genetic testing.
Motivational interviewing (MI): At least 2 phone calls delivered by trained genetic health coaches using motivational interviewing and providing genetic testing information.
|
|---|---|---|---|
|
Motivators of Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q1: Knowing my genetic status could help me plan my treatment- 6 Month Survey
|
3.80 score on a scale
Standard Deviation 0.86
|
3.63 score on a scale
Standard Deviation 0.88
|
3.64 score on a scale
Standard Deviation 0.91
|
|
Motivators of Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q1: Knowing my genetic status could help me plan my treatment- 12 Month Survey
|
3.69 score on a scale
Standard Deviation 0.91
|
3.61 score on a scale
Standard Deviation 0.93
|
3.52 score on a scale
Standard Deviation 0.90
|
|
Motivators of Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q2: Knowing my genetic status would impact my cancer screening- 6 months
|
3.65 score on a scale
Standard Deviation 1.04
|
3.67 score on a scale
Standard Deviation 0.86
|
3.51 score on a scale
Standard Deviation 0.96
|
|
Motivators of Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q2: Knowing my genetic status would impact my cancer screening- 12 months
|
3.62 score on a scale
Standard Deviation 0.96
|
3.59 score on a scale
Standard Deviation 0.98
|
3.44 score on a scale
Standard Deviation 0.96
|
|
Motivators of Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q3: I would be relieved to know my risk for hereditary cancer- 6 months
|
3.71 score on a scale
Standard Deviation 0.90
|
3.60 score on a scale
Standard Deviation 0.86
|
3.66 score on a scale
Standard Deviation 0.91
|
|
Motivators of Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q3: I would be relieved to know my risk for hereditary cancer- 12 months
|
3.63 score on a scale
Standard Deviation 0.93
|
3.62 score on a scale
Standard Deviation 0.92
|
3.63 score on a scale
Standard Deviation 0.98
|
|
Motivators of Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q4: I want to make sure my family has information that could affect their health- 6 months
|
4.17 score on a scale
Standard Deviation 0.81
|
4.16 score on a scale
Standard Deviation 0.70
|
4.15 score on a scale
Standard Deviation 0.76
|
|
Motivators of Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q4: I want to make sure my family has information that could affect their health- 12 months
|
4.04 score on a scale
Standard Deviation 0.95
|
3.99 score on a scale
Standard Deviation 0.82
|
3.96 score on a scale
Standard Deviation 0.81
|
|
Motivators of Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q5: A healthcare provider recommended it- 6 Months
|
3.54 score on a scale
Standard Deviation 0.97
|
3.29 score on a scale
Standard Deviation 1.07
|
3.47 score on a scale
Standard Deviation 1.05
|
|
Motivators of Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing
Q5: A healthcare provider recommended it- 12 Months
|
3.37 score on a scale
Standard Deviation 1.05
|
3.41 score on a scale
Standard Deviation 1.13
|
3.38 score on a scale
Standard Deviation 1.04
|
Adverse Events
Arm 1 - Usual Care (UC)
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Arm 2 - Virtual Genetics Navigator (Digital Intervention)
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching)
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
University of Michigan Rogel Cancer Center ClinicalTrials.gov Admin
University of Michigan Rogel Cancer Center
Phone: 734-936-9499
Email: [email protected]
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place