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Intestinal Ketone Bodies Interfere With the Glycemic Control

NCT05154461 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 8

Last updated 2022-09-30

No results posted yet for this study

Summary

The ketone body (KB) ß-hydroxybutyrate will be given to eight fasting healthy volunteers of both sexes in order to observe the effects after an oral glucose tolerance test (OGTT) over 2 h. Then, a standard lunch will be served at 12.00, as well as an afternoon snack at 15.00. Each participant will be its own control and participates in a randomised two-way cross over design; the KB are released in the stomach-duodenum, or in the ileum-colon. Peripheral blood samples are taken for endpoint GLP-1 analyses.

Conditions

  • Healthy Adult Volunteers

Interventions

OTHER

Alginate

BHB covered in alginate will be realised in stomach-duodenum

OTHER

Pea-protein

BHB covered in pea-protein will be released in ileum-colon

Sponsors & Collaborators

  • Göteborg University

    lead OTHER

Principal Investigators

  • Lars Fändriks, MD, PhD · Göteborg University

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-12-05
Primary Completion
2022-07-01
Completion
2022-09-01

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05154461 on ClinicalTrials.gov