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Radiofrequency Ablation Versus I-131 for Solitary Autonomous Thyroid Nodules

NCT05142904 · Status: TERMINATED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2025-07-17

No results posted yet for this study

Summary

The purpose of this study is to compare treatment of hyperthyroidism with radiofrequency ablation or I-131 for solitary autonomous thyroid nodules.

Conditions

  • Thyroid Nodule, Toxic or With Hyperthyroidism
  • Autonomous Thyroid Function
  • Thyroid Nodule; Hyperthyroidism
  • Radiofrequency Ablation
  • Iodine Hyperthyroidism
  • Iodine Adverse Reaction

Interventions

DEVICE

Radiofrequency ablation

Ultrasound-guided radiofrequency ablation of the solitary autonomous thyroid nodule.

DRUG

Radioactive iodine

I-131 according to standardized doses-calculation.

DRUG

Radioactive iodine

I-131 according to local standard.

Sponsors & Collaborators

  • ZonMw: The Netherlands Organisation for Health Research and Development

    collaborator OTHER

  • University of Twente

    collaborator OTHER

  • Amsterdam UMC

    collaborator OTHER

  • Rijnstate Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-11-17
Primary Completion
2024-11-01
Completion
2024-11-01

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05142904 on ClinicalTrials.gov