Regional Anaesthesia in Intensive Care Unit

Summary

Pain is a major problem in Intensive Care Unit (ICU). Adequate pain management not only means decreasing the pain intensity, but also improving the functionality and allowing the early mobilization that is a prerequisite for improving recovery and decreasing the risk of complications in ICU. The complex problems involved in pain, analgesic interventions, and outcome have been emphasized in several surveys over the past decades, but apparently with only small improvements, despite the existence of several guidelines for perioperative pain management.

Regional analgesia techniques (peripheral and neuraxial nerve blocks) have the potential to decrease the physiological stress response to trauma or surgery, reducing the possibility of surgical complications and improving the outcomes. Recent studies suggested that surgical and trauma ICU patients receive opioid-hypnotics continuous infusions to prevent pain and agitation that could increase the risk of posttraumatic stress disorder and chronic neuropathic pain symptoms, and chronic opioid use. Also they may reduce the total amount of opioid analgesics necessary to achieve adequate pain control and the development of potentially dangerous side effects. The use of the regional anesthesia technique in the ICU, however, can, in part, be limited by the presence of hemodynamic instability, bleeding diathesis, and by the fear of the performing procedures potentially associated with significant side effects in heavily sedated patients.

Although regional anesthesia emerges as a new and very interesting player for pain management in ICU, today very few data exists about the use of RA (including PNB and neuraxial nerves blocks) by the practicians in ICU/stepdown units. The main objective of this study is to assess the use of RA for pain management both initiates in the operative room for surgical patients then transferred in ICU/stepdown units and performs directly by the practicians in ICU/stepdown units, in several french units.

Conditions

• Intensive Care Unit

Sponsors & Collaborators

• Hôpital Edouard Herriot

  collaborator OTHER

• Rangueil Hospital

  collaborator OTHER

• Hospices Civils de Lyon

  collaborator OTHER

• Hopital Louis Pradel

  collaborator OTHER

• Hôpital Saint Camille

  collaborator UNKNOWN

• Hôpital de la Timone

  collaborator OTHER

• University Hospital, Grenoble

  collaborator OTHER

• University Hospital, Lille

  collaborator OTHER

• Saint Antoine University Hospital

  collaborator OTHER

• University Hospital, Strasbourg

  collaborator OTHER

• University Hospital, Marseille

  collaborator OTHER

• Centre Hospitalier Universitaire de Nīmes

  collaborator OTHER

• CH Aix

  collaborator UNKNOWN

• CH Martigues

  collaborator UNKNOWN

• CH Alberville

  collaborator UNKNOWN

• CH Chambery

  collaborator UNKNOWN

• Rennes University Hospital

  collaborator OTHER

• Bichat Hospital

  collaborator OTHER

• University Hospital, Clermont-Ferrand

  lead OTHER

Principal Investigators

• Raïko Blondonnet · [email protected]

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2021-10-18

Primary Completion

2021-11-20

Completion

2021-12-31

Countries

• France

Study Locations