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Dapsone Use in Patients With Aneurysmal Subarachnoid Hemorrhage.

NCT05131295 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 49

Last updated 2021-11-23

No results posted yet for this study

Summary

Dapsone is a drug that has been used clinically for several decades due to its anti-infective effect, making it widely available. Its neuroprotective effects have been found through its glutamate receptors antagonistic effect. Their main objective was to study the neuroprotective properties in patients with aneurysmal subarachnoid hemorrhage and high-risk factors for the development of cerebral vasospasm. Both the placebo and the dapsone used in this clinical trial were provided by the institution's neurochemistry laboratory.

Conditions

  • Subarachnoid Hemorrhage
  • Brain Ischemia
  • Subarachnoid Hemorrhage, Aneurysmal
  • Aneurysmal Subarachnoid Hemorrhage
  • Delayed Cerebral Ischemia
  • Vasospasm, Cerebral

Interventions

DRUG

Dapsone

Dapsone is a drug that has been used clinically for several decades due to its anti-infective effect. It has an anti-inflammatory effect due to its inhibitory action on neutrophils. Neuroprotective effects have been found experimentally with the use of dapsone, predominantly through its glutamate receptors antagonistic effect; these are the main receptors involved in neuronal excitotoxicity.

DRUG

Aluminum Hydroxide Gel

Aluminum Hydroxide Gel is an antacid that works quickly to lower the acid in the stomach

Sponsors & Collaborators

  • El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez

    lead OTHER

Principal Investigators

  • Edgar Nathal, MD · El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
PARALLEL

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-09-05
Primary Completion
2008-12-07
Completion
2009-03-10

Countries

  • Mexico

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05131295 on ClinicalTrials.gov