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THC Memory & Reward Learning Pilot

NCT05116527 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2025-03-17

No results posted yet for this study

Summary

Tetrahydrocannabidiol (THC) is the psychoactive chemical in cannabis that makes people high. This study aims to dissect acute impairment of various forms of memory and learning by THC in cannabis compared to placebo. Impairment will be assessed via a short cognitive test battery and then subjects will complete four tasks in the fMRI scanner.

Conditions

  • Marijuana
  • THC
  • Cannabis

Interventions

DRUG

Marijuana, Hash, THC, or Grass

Marijuana flower with a high THC content

DRUG

Placebo

Placebo THC - marijuana flower with no THC content

Sponsors & Collaborators

  • Yale University

    collaborator OTHER

  • Hartford Hospital

    lead OTHER

Principal Investigators

  • Godfrey Pearlson, M.D · Yale University

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-07-07
Primary Completion
2025-12-31
Completion
2025-12-31
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05116527 on ClinicalTrials.gov