Trial Outcomes & Findings for Cigarette and E-cigarette Flavors Manipulations in the Experimental Tobacco Marketplace (NCT NCT05110872)
NCT ID: NCT05110872
Last Updated: 2025-10-07
Results Overview
Participants will complete purchasing trials in an Experimental Tobacco Marketplace (ETM) with cigarettes increasing in price. Product availability in the ETM depended on the experimental condition. The average percentage of budget spent on e-cigarettes as a function of the restriction of cigarettes and/or e-cigarettes will be assessed.
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
302 participants
Primary outcome timeframe
1 day
Results posted on
2025-10-07
Participant Flow
Participant milestones
| Measure |
Menthol Cigarette Smokers
Adults (21 y.o. and older) who smoke ate least 10 menthol cigarettes per day will be recruited.
Cigarette flavor restricted and e-cigarette flavor restricted: 1) Tobacco cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
Cigarette flavor restricted and e-cigarette flavor unrestricted: 1) Tobacco cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored and a range of flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
Cigarette flavor unrestricted and e-cigarette flavor restricted: 1) Tobacco and menthol cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
Cigarette flavor unrestricted and e-cigarette flavor unrestricted: 1) Tobacco and menthol cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored and a range of flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
|
Non-menthol Cigarette Smokers
Adults (21 y.o. and older) who smoke ate least 10 non-menthol cigarettes per day will be recruited.
Cigarette flavor restricted and e-cigarette flavor restricted: 1) Tobacco cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
Cigarette flavor restricted and e-cigarette flavor unrestricted: 1) Tobacco cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored and a range of flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
Cigarette flavor unrestricted and e-cigarette flavor restricted: 1) Tobacco and menthol cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
Cigarette flavor unrestricted and e-cigarette flavor unrestricted: 1) Tobacco and menthol cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored and a range of flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
|
|---|---|---|
|
Overall Study
STARTED
|
140
|
162
|
|
Overall Study
COMPLETED
|
140
|
162
|
|
Overall Study
NOT COMPLETED
|
0
|
0
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Cigarette and E-cigarette Flavors Manipulations in the Experimental Tobacco Marketplace
Baseline characteristics by cohort
| Measure |
Menthol Cigarette Smokers
n=130 Participants
Adults (21 y.o. and older) who smoke ate least 10 menthol cigarettes per day will be recruited.
Cigarette flavor restricted and e-cigarette flavor restricted: 1) Tobacco cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
Cigarette flavor restricted and e-cigarette flavor unrestricted: 1) Tobacco cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored and a range of flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
Cigarette flavor unrestricted and e-cigarette flavor restricted: 1) Tobacco and menthol cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
Cigarette flavor unrestricted and e-cigarette flavor unrestricted: 1) Tobacco and menthol cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored and a range of flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
|
Non-menthol Cigarette Smokers
n=133 Participants
Adults (21 y.o. and older) who smoke ate least 10 non-menthol cigarettes per day will be recruited.
Cigarette flavor restricted and e-cigarette flavor restricted: 1) Tobacco cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
Cigarette flavor restricted and e-cigarette flavor unrestricted: 1) Tobacco cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored and a range of flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
Cigarette flavor unrestricted and e-cigarette flavor restricted: 1) Tobacco and menthol cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
Cigarette flavor unrestricted and e-cigarette flavor unrestricted: 1) Tobacco and menthol cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored and a range of flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
|
Total
n=263 Participants
Total of all reporting groups
|
|---|---|---|---|
|
Age, Continuous
|
49.15 years
STANDARD_DEVIATION 13.31 • n=99 Participants
|
49.77 years
STANDARD_DEVIATION 13.95 • n=107 Participants
|
49.46 years
STANDARD_DEVIATION 13.63 • n=206 Participants
|
|
Sex/Gender, Customized
Female
|
70 Participants
n=99 Participants
|
58 Participants
n=107 Participants
|
128 Participants
n=206 Participants
|
|
Sex/Gender, Customized
Male
|
60 Participants
n=99 Participants
|
75 Participants
n=107 Participants
|
135 Participants
n=206 Participants
|
|
Ethnicity (NIH/OMB)
Hispanic or Latino
|
20 Participants
n=99 Participants
|
15 Participants
n=107 Participants
|
35 Participants
n=206 Participants
|
|
Ethnicity (NIH/OMB)
Not Hispanic or Latino
|
110 Participants
n=99 Participants
|
118 Participants
n=107 Participants
|
228 Participants
n=206 Participants
|
|
Ethnicity (NIH/OMB)
Unknown or Not Reported
|
0 Participants
n=99 Participants
|
0 Participants
n=107 Participants
|
0 Participants
n=206 Participants
|
|
Race (NIH/OMB)
American Indian or Alaska Native
|
0 Participants
n=99 Participants
|
2 Participants
n=107 Participants
|
2 Participants
n=206 Participants
|
|
Race (NIH/OMB)
Asian
|
2 Participants
n=99 Participants
|
2 Participants
n=107 Participants
|
4 Participants
n=206 Participants
|
|
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
|
0 Participants
n=99 Participants
|
1 Participants
n=107 Participants
|
1 Participants
n=206 Participants
|
|
Race (NIH/OMB)
Black or African American
|
12 Participants
n=99 Participants
|
2 Participants
n=107 Participants
|
14 Participants
n=206 Participants
|
|
Race (NIH/OMB)
White
|
112 Participants
n=99 Participants
|
124 Participants
n=107 Participants
|
236 Participants
n=206 Participants
|
|
Race (NIH/OMB)
More than one race
|
4 Participants
n=99 Participants
|
2 Participants
n=107 Participants
|
6 Participants
n=206 Participants
|
|
Race (NIH/OMB)
Unknown or Not Reported
|
0 Participants
n=99 Participants
|
0 Participants
n=107 Participants
|
0 Participants
n=206 Participants
|
|
Region of Enrollment
United States
|
130 participants
n=99 Participants
|
133 participants
n=107 Participants
|
263 participants
n=206 Participants
|
|
Cigarettes per day
|
19.79 cigarettes per day
STANDARD_DEVIATION 13.05 • n=99 Participants
|
18.18 cigarettes per day
STANDARD_DEVIATION 8.82 • n=107 Participants
|
18.99 cigarettes per day
STANDARD_DEVIATION 10.94 • n=206 Participants
|
PRIMARY outcome
Timeframe: 1 dayParticipants will complete purchasing trials in an Experimental Tobacco Marketplace (ETM) with cigarettes increasing in price. Product availability in the ETM depended on the experimental condition. The average percentage of budget spent on e-cigarettes as a function of the restriction of cigarettes and/or e-cigarettes will be assessed.
Outcome measures
| Measure |
Menthol Cigarette Smokers
n=130 Participants
Adults (21 y.o. and older) who smoke ate least 10 menthol cigarettes per day will be recruited.
Cigarette flavor restricted and e-cigarette flavor restricted: 1) Tobacco cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
Cigarette flavor restricted and e-cigarette flavor unrestricted: 1) Tobacco cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored and a range of flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
Cigarette flavor unrestricted and e-cigarette flavor restricted: 1) Tobacco and menthol cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
Cigarette flavor unrestricted and e-cigarette flavor unrestricted: 1) Tobacco and menthol cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored and a range of flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
|
Non-menthol Cigarette Smokers
n=133 Participants
Adults (21 y.o. and older) who smoke ate least 10 non-menthol cigarettes per day will be recruited.
Cigarette flavor restricted and e-cigarette flavor restricted: 1) Tobacco cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
Cigarette flavor restricted and e-cigarette flavor unrestricted: 1) Tobacco cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored and a range of flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
Cigarette flavor unrestricted and e-cigarette flavor restricted: 1) Tobacco and menthol cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
Cigarette flavor unrestricted and e-cigarette flavor unrestricted: 1) Tobacco and menthol cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored and a range of flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
|
|---|---|---|
|
Spent the Budget on E-cigarettes for Each Condition
Cigarette and E-cigarette Restriction
|
10.64 percentage of spent budget
Standard Error 1.36
|
14.87 percentage of spent budget
Standard Error 1.44
|
|
Spent the Budget on E-cigarettes for Each Condition
Cigarette Restriction
|
14.74 percentage of spent budget
Standard Error 1.62
|
14.65 percentage of spent budget
Standard Error 1.38
|
|
Spent the Budget on E-cigarettes for Each Condition
E-cigarette restriction
|
8.20 percentage of spent budget
Standard Error 1.17
|
15.03 percentage of spent budget
Standard Error 1.42
|
|
Spent the Budget on E-cigarettes for Each Condition
No Restriction on Cigarettes or E-cigarettes
|
11.35 percentage of spent budget
Standard Error 1.45
|
16.07 percentage of spent budget
Standard Error 1.47
|
PRIMARY outcome
Timeframe: 1 dayParticipants will complete purchasing trials in an Experimental Tobacco Marketplace (ETM) with cigarettes increasing in price. Product availability in the ETM depended on the experimental condition. The average percentage of the budget spent on cigarettes as a function of the restriction of cigarettes and/or e-cigarettes will be assessed.
Outcome measures
| Measure |
Menthol Cigarette Smokers
n=130 Participants
Adults (21 y.o. and older) who smoke ate least 10 menthol cigarettes per day will be recruited.
Cigarette flavor restricted and e-cigarette flavor restricted: 1) Tobacco cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
Cigarette flavor restricted and e-cigarette flavor unrestricted: 1) Tobacco cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored and a range of flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
Cigarette flavor unrestricted and e-cigarette flavor restricted: 1) Tobacco and menthol cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
Cigarette flavor unrestricted and e-cigarette flavor unrestricted: 1) Tobacco and menthol cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored and a range of flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
|
Non-menthol Cigarette Smokers
n=133 Participants
Adults (21 y.o. and older) who smoke ate least 10 non-menthol cigarettes per day will be recruited.
Cigarette flavor restricted and e-cigarette flavor restricted: 1) Tobacco cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
Cigarette flavor restricted and e-cigarette flavor unrestricted: 1) Tobacco cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored and a range of flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
Cigarette flavor unrestricted and e-cigarette flavor restricted: 1) Tobacco and menthol cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
Cigarette flavor unrestricted and e-cigarette flavor unrestricted: 1) Tobacco and menthol cigarettes will be available in the Experimental Tobacco Marketplace 2) Tobacco-flavored and a range of flavored e-cigarettes will be available in the Experimental Tobacco Marketplace
|
|---|---|---|
|
Spent Budget on Cigarettes for Each Condition
Cigarette and E-cigarette Restriction
|
55.04 percentage of spent budget
Standard Error 2.56
|
65.82 percentage of spent budget
Standard Error 2.03
|
|
Spent Budget on Cigarettes for Each Condition
Cigarette Restriction
|
53.05 percentage of spent budget
Standard Error 2.57
|
65.80 percentage of spent budget
Standard Error 2.02
|
|
Spent Budget on Cigarettes for Each Condition
E-cigarette Restriction
|
73.60 percentage of spent budget
Standard Error 2.13
|
65.72 percentage of spent budget
Standard Error 2.00
|
|
Spent Budget on Cigarettes for Each Condition
No Restriction on Cigarettes or E-cigarettes
|
72.05 percentage of spent budget
Standard Error 2.14
|
65.20 percentage of spent budget
Standard Error 2.03
|
Adverse Events
Menthol Cigarette Smokers
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Non-menthol Cigarette Smokers
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Dr. Freitas-Lemos
Fralin Biomedical Research Institute at Virginia Tech Carilion
Phone: 540-526-2106
Email: [email protected]
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place