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Reconsolidation Therapy With Propranolol as a Treatment for Chronic Pain

NCT05085782 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 48

Last updated 2025-09-26

No results posted yet for this study

Summary

The primary aim of this study is to document the feasibility and acceptability of an intervention consisting of pain neuroscience education and reconsolidation therapy with propranolol in adults suffering from chronic pain (chronic low back pain or fibromyalgia).

The secondary aim of the study is to estimate the effect size of the intervention on pain and function one month post-intervention, and to obtain data for sample-size calculation for a subsequent randomized controlled trial.

Conditions

  • Chronic Low-back Pain
  • Fibromyalgia

Interventions

DRUG

Propranolol Hydrochloride

6 weekly doses (40 to 80 mg) 1h before the reactivation procedure

DRUG

Placebo

6 weekly doses (40 to 80 mg) 1h before the reactivation procedure

BEHAVIORAL

Reactivation procedure

Description/visualization of painful movements/activities

BEHAVIORAL

Pain neuroscience education

In the form of 10 videos that participants will watch on their own time

Sponsors & Collaborators

  • Université de Sherbrooke

    lead OTHER

Principal Investigators

  • Guillaume Leonard, PhD · Université de Sherbrooke

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-02-07
Primary Completion
2024-12-30
Completion
2025-08-31

Countries

  • Canada

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05085782 on ClinicalTrials.gov