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Effect of Enzymes on Dental Biofilm Accumulation in Healthy Individuals

NCT05082103 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2022-06-09

No results posted yet for this study

Summary

The purpose of the study is to assess the effect of enzyme containing lozenges on dental plaque accumulation in healthy adults.

Conditions

  • Dental Plaque

Interventions

OTHER

Enzyme lozenge 1

Participants are instructed to take one enzyme containing lozenge three times daily, at least 30 min after a meal, for 14 days. No normal oral hygiene procedures are allowed during the intervention period.

OTHER

Enzyme lozenge 2

Participants are instructed to take one lozenge with 3x higher enzyme concentration three times daily, at least 30 min after a meal, for 14 days. No normal oral hygiene procedures are allowed during the intervention period.

OTHER

Placebo lozenge

Participants are instructed to take one placebo lozenge three times daily, at least 30 min after a meal, for 14 days. No normal oral hygiene procedures are allowed during the intervention period.

Sponsors & Collaborators

  • University of Aarhus

    collaborator OTHER

  • Novozymes A/S

    lead INDUSTRY

Principal Investigators

  • Mette Rose Jørgensen, DDS, PhD · Novozymes A/S

  • Sebastian Schlafer, DDS, PhD · Aarhus University, Department of Dentistry and Oral Health

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-09-15
Primary Completion
2022-03-31
Completion
2022-03-31

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05082103 on ClinicalTrials.gov