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Effect of Inulin on Gut Microbiota and Gut Barrier in Chronic Kidney Disease

NCT05071131 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2024-06-25

No results posted yet for this study

Summary

An adequate fiber intake is crucial for a well-balanced diet and reduces the risk of chronic diseases. However, nutritional recommendations for chronic kidney disease patients lead to an insufficient fiber intake with possible maladaptive effects on the gut microbiome. Therefore, we want to study the effects of a 35-day inulin supplementation on the gut microbiome, gut barrier function, bacterial metabolites and immune cell states in chronic kidney disease patients.

Conditions

  • Chronic Kidney Disease 5D

Interventions

DIETARY_SUPPLEMENT

Inulin

1 sachet à 15 grams daily for 7 days, followed by 2 sachets à 15 grams daily for 28 days

DIETARY_SUPPLEMENT

Placebo

1 sachet à 15 grams daily for 7 days, followed by 2 sachets à 15 grams daily for 28 days

Sponsors & Collaborators

  • Charite University, Berlin, Germany

    lead OTHER

Principal Investigators

  • Anja Mähler, PhD · Charite University, Berlin, Germany

  • Nicola Wilck, MD · Charite University, Berlin, Germany

  • Victoria McParland, PhD · Charite University, Berlin, Germany

  • Johannes Holle, MD · Charite University, Berlin, Germany

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-02-01
Primary Completion
2026-02-01
Completion
2027-02-01

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05071131 on ClinicalTrials.gov