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Genetic Diagnosis and Human Growth Hormone Treatment in Small for Gestational Age Children With Short Stature

NCT05070234 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 150

Last updated 2021-10-07

No results posted yet for this study

Summary

This study is a multi-center, retrospective and non-interventional research. In this study, a total of 150 short children who were small for gestational age and had been treated with recombinant human growth hormone (rhGH) are selected for genetic testing. The aims of this study are to analyze the genetic etiology of SGA children with short stature, and to compare the efficacy and safety of rhGH treatment in subjects with different etiologies.

Conditions

  • Small for Gestational Age Infant
  • Silver-Russell Syndrome
  • Genetic Diseases, Inborn

Interventions

GENETIC

Blood collection for genetic analysis

Genetic tests in this study are sequential testing, including MS-MLPA, whole exome sequencing, whole genome sequencing, as well as RNA-seq.

Sponsors & Collaborators

  • Shanghai Children's Hospital

    collaborator OTHER

  • Second Affiliated Hospital of Guangzhou Medical University

    collaborator OTHER

  • Shenzhen Children's Hospital

    collaborator OTHER_GOV

  • Tongji Hospital

    collaborator OTHER

  • The Children's Hospital of Zhejiang University School of Medicine

    collaborator OTHER

  • Chengdu Women's and Children's Central Hospital

    collaborator OTHER

  • West China Second University Hospital

    collaborator OTHER

  • The First Affiliated Hospital with Nanjing Medical University

    collaborator OTHER

  • Changchun GeneScience Pharmaceutical Co., Ltd.

    collaborator INDUSTRY

  • Chunxiu Gong

    lead OTHER

Principal Investigators

  • Chunxiu Gong, doctor · Beijing Children's Hospital

Eligibility

Min Age
2 Years
Max Age
20 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-10-11
Primary Completion
2022-08-30
Completion
2022-08-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05070234 on ClinicalTrials.gov