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Understanding Motivation in Parkinson's Patients Through Neurophysiology

NCT05065151 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 70

Last updated 2025-04-10

No results posted yet for this study

Summary

The study aims to better understand motivation and value-based decision-making in Parkinson's patients through neurophysiology using Medtronic's Percept DBS device. By combining behavioral tasks with neural recordings, the study seeks to uncover how DBS affects motivation, particularly in relation to effort, reward, and timing.

Conditions

  • Parkinson Disease
  • Deep Brain Stimulation
  • Motivation

Interventions

OTHER

Stimulation on

Stimulation from Percept DBS will be on while the patient is playing a decision-making game on a computer-based application.

OTHER

Stimulation off

Stimulation from Percept DBS will be off while the patient is playing a decision-making game on a computer-based application.

BEHAVIORAL

Decision Making Task

Patients will be playing a decision making task through a computer-based application.

Sponsors & Collaborators

Principal Investigators

  • Simon J Little, MBBS, PhD · University of California, San Francisco

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-10-30
Primary Completion
2030-12-01
Completion
2030-12-01

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05065151 on ClinicalTrials.gov