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Exercise in Testicular Germ Cell Cancer Survivors

NCT05063760 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2023-12-05

No results posted yet for this study

Summary

Regular exercise is effective in prevention \& treatment of chronic diseases. Exercise can reduce late toxicity of chemotherapy, commonly found in cancer survivors, which is yet to be translated into clinical practice.

Mechanisms of exercise benefits in oncologic patients are far from being elucidated, and include increase in muscle mass, reduction of fat mass, systemic inflammation and cardiometabolic risk. Synchronization of exercise adaptive response is, to an extent, mediated by bioactive molecules released from muscle, with anti-inflammatory \& tumor-suppressing properties. Muscle satellite cells are a source of regeneration, muscle structural integrity \& functional capacity. Phenotypes of muscle cells, such as secretory profile, lipid \& glucose metabolism, mirror clinical phenotypes of the donor. Importantly, muscle cells' metabolism in vitro can be modulated by 8-12 week training in vivo. Epigenetic mechanisms regulating muscle \& systemic metabolism in cancer survivors are not yet understood.

Conditions

  • Testicular Germ Cell Tumor

Interventions

BEHAVIORAL

aerobic-strength exercise intervention (6-months)

6 month supervised exercise intervention in TGCT survivors (1 hour sessions 3 x per week),

Sponsors & Collaborators

  • Comenius University

    collaborator OTHER

  • Slovak Academy of Sciences

    lead OTHER_GOV

Principal Investigators

  • Barbara Ukropcova, MD, PhD, Prof · Biomedical Research Center, Slovak Acad Sci

Study Design

Allocation
NON_RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
25 Years
Max Age
55 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-01-15
Primary Completion
2023-12-01
Completion
2024-06-30

Countries

  • Slovakia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05063760 on ClinicalTrials.gov