Local Consolidative Therapy in Colorectal Cancer
NCT05062720 · Status: WITHDRAWN · Phase: PHASE2 · Type: INTERVENTIONAL
Last updated 2022-12-09
Summary
This is a Phase II randomized multisite trial to study the effect of a combination of local consolidative therapy with systemic therapy in subjects with oligometastatic colorectal cancer who have progressed on the first line of therapy.
Conditions
- Colorectal Cancer Metastatic
Interventions
- RADIATION
-
Local consolidative therapy
Local Consolidative Therapy (LCT) will be defined as surgical resection or stereotactic body radiotherapy (SBRT) or a combination of both strategies
Sponsors & Collaborators
-
Varian Medical Systems
collaborator INDUSTRY -
Fox Chase Cancer Center
lead OTHER
Principal Investigators
-
Joshua Meyer, MD · Fox Chase Cancer Center
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- CROSSOVER
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2021-07-29
- Primary Completion
- 2023-12-31
- Completion
- 2025-10-31
Countries
- United States
Study Locations
More Related Trials
-
Comprehensive Therapy to Relieving the Risk of Recurrence and Metastasis for Colorectal Cancer
NCT00689364 ·Status: UNKNOWN
-
Treatment Strategies for Primarily Generalized Colorectal Cancer
NCT01056809 ·Status: TERMINATED ·Phase: NA
-
Study of TF2 Carcinoembryonic Antigen (CEA) Antibody in Patients With Metastatic Colorectal Cancer
NCT01273402 ·Status: WITHDRAWN ·Phase: PHASE1
-
Consolidative Radiotherapy Plus Maintenance Chemotherapy for Metastatic Colorectal Cancer
NCT03142282 ·Status: UNKNOWN ·Phase: PHASE2
-
QOL & Functional Outcomes After Combined Modality Tx for Anal CA: Comparison of Conventional vs IMRT
NCT00568425 ·Status: TERMINATED
-
Pretargeted Radioimmunotherapy in Metastatic Colorectal Cancer
NCT02300922 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Intensity Modulated Radiation Therapy (IMRT) for Patients With Rectal Cancer
NCT01148056 ·Status: TERMINATED ·Phase: PHASE2
-
Short-course Preoperative Chemoradiotherapy Followed by Delayed Operation for Locally Advanced Rectal Cancer
NCT01129700 ·Status: COMPLETED ·Phase: PHASE2
-
Study of Radiation Therapy in Combination With Xeloda, for Initially Metastatic, Low and Middle Rectal Cancer
NCT03634202 ·Status: TERMINATED ·Phase: NA
-
A Study of Radiotherapy Combined With Raltitrexed and Irinotecan in Metastatic or Locally Recurrent Colorectal Cancer
NCT04499586 ·Status: UNKNOWN ·Phase: PHASE2
-
PET and CT Scans in Patients With Locally Advanced Primary Rectal Cancer That Can Be Removed During Surgery
NCT00004891 ·Status: COMPLETED ·Phase: NA
-
Transanal Decompression Tube Versus Stent for Acute Malignant Left-sided Colonic and Rectal Obstruction
NCT02585271 ·Status: TERMINATED ·Phase: NA
-
Predictors of Tumor Response and of Radiation Therapy Side Effects in Patients With Gastrointestinal Cancers
NCT01445327 ·Status: TERMINATED
-
Pre-operative 3-DCRT vs IMRT for Locally Advanced Rectal Cancer
NCT02151019 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
The Role of 18F-FDG and 68Ga-FAPI PET/CT in the Diagnosis and the Efficacy Evaluation of Advanced Colorectal Cancer (peritoneal Metastasis With/without Other Metastases)
NCT06601075 ·Status: RECRUITING
-
Hyperthermic Intraperitoneal Treatment of rmhTNF for CRCPM: Phase II Clinical Trial
NCT05755685 ·Status: UNKNOWN ·Phase: PHASE2
-
Treatment of Unresectable Colorectal Metastases by Radiofrequency Ablation Combined or Not With Resection, With or Without Neoadjuvant Chemotherapy.
NCT00210106 ·Status: COMPLETED ·Phase: NA
-
Delayed Systemic Therapy Following Destructive Local Treatment of Pulmonary Oligometastases After No Evidence of Disease (NED) in Colorectal Cancer.
NCT06778382 ·Status: RECRUITING ·Phase: PHASE2
-
Computed Tomography-guided Brachytherapy Plus Chemotherapy for Locally Recurrent Rectum Cancer
NCT02423226 ·Status: COMPLETED ·Phase: PHASE2
-
Curative Proton Beam Therapy for Patients With Lung Metastasis of Colorectal Cancer
NCT03566355 ·Status: RECRUITING ·Phase: NA
-
Combined Use of Raltitrexed and S-1 as Treatment for Patients With Metastasizing Colorectal Cancer
NCT02618356 ·Status: UNKNOWN ·Phase: PHASE2
-
Study of Biomarkers in Tissue Samples From Patients With Metastatic Colon Cancer
NCT01012804 ·Status: WITHDRAWN
-
Chemokine and Co-stimulatory Molecule-modified Mesenchymal Stem Cells for the Treatment of Advanced Colorectal Cancer
NCT06446050 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
Local Liver Treatment for Multi-organ Colorectal Cancer Metastases
NCT06449937 ·Status: RECRUITING ·Phase: NA
-
Surgery With or Without Radiofrequency Ablation Followed by Irinotecan in Treating Patients With Colorectal Cancer That is Metastatic to the Liver
NCT00030563 ·Status: COMPLETED ·Phase: PHASE2