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Prognostic Impact of Cardiac Diastolic Function and Coronary Microvascular Function

NCT05058833 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 800

Last updated 2025-03-14

No results posted yet for this study

Summary

The DIAST-CMD registry (Prognostic Impact of Cardiac Diastolic Function and Coronary Microvascular Function) is prospective registry which enrolled patients who underwent echocardiography, cnically-indicated invasive coronary angiography and comprehensive physiologic assessments including fractional flow reserve (FFR), CFR, and IMR measurements for at least 1 vessel from Samsung Medical Center. Patients with hemodynamic instability, severe LV dysfunction (left ventricular ejection fraction\<40%), a culprit vessel of acute coronary syndrome, severe valvular stenosis or regurgitation were excluded.

Conditions

Interventions

DIAGNOSTIC_TEST

Echocardiography

Echocardiographic grades of diastolic function was defined according to 2016 ASE/EACVI recommendations for the evaluation of LV diastolic function. Cardiac diastolic dysfunction was defined as elevated E/e'≥15.

DIAGNOSTIC_TEST

Coronary flow reserve and index of microcirculatory dysfunction

Coronary microcirculatory dysfunction was defined as having both depressed CFR (≤2.0) and elevated IMR (≥23U).

Sponsors & Collaborators

  • Chonnam National University Hospital

    collaborator OTHER

  • Chosun University Hospital

    collaborator OTHER

  • Gangneung Asan Hospital

    collaborator OTHER

  • Samsung Medical Center

    lead OTHER

Principal Investigators

  • Joo Myung Lee, MD, MPH, PhD · Samsung Medical Center

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-04-08
Primary Completion
2024-12-31
Completion
2024-12-31

Countries

  • United States
  • South Korea

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05058833 on ClinicalTrials.gov