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Wide Excision of Soft Tissue Sarcomas in Combination With Interstitial Radiation Therapy

NCT05057195 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 78

Last updated 2024-04-01

No results posted yet for this study

Summary

Intraoperatively, in the bed of the removed tumor, a surgical mesh is sutured onto which the intrastats are fixed. On days 2-3, topometric preparation is carried out, the choice of the amount of irradiation, the calculation of the program. On the 4-5th day after the operation, a course of intra-tissue radiation therapy begins in a single dose of 3 to 5 Gy in 10 fractions 2 times a day with an interval between fractions of 6 hours, the planned total dose is from 30 to 50 Gy. (from 40 to 70 IGy). Follow-up examination after 4 weeks and then every 3 months for 24 months

Conditions

  • Sarcoma
  • Soft Tissue Sarcoma

Interventions

RADIATION

Interstitial radiation therapy

From 30 to 50 Gy,

RADIATION

Postoperative external beam therapy

50 Gy and locally on the tumor bed up to 10-26 Gy, depending on the status of the resection margin

Sponsors & Collaborators

  • Blokhin's Russian Cancer Research Center

    lead OTHER

Principal Investigators

  • Aslan Valiev, PhD · N.N. Blokhin NMRCO

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-01-10
Primary Completion
2025-12-31
Completion
2025-12-31

Countries

  • Russia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05057195 on ClinicalTrials.gov