Protocol Design for Evaluating the Immunity of Bivalve Fluids From Anodonta Cygnea in SARS and COVID-19

Summary

The present work proposes to find if a bio-active composite in the hemolymph or plasma of the freshwater bivalve Anodonta cygnea is able to offer immunity and specificity for meliorating the major symptoms in human SARS and COVID-19 lineage infection. The Methodology concerns in silico procedures using organic fluids from 54 bivalves (in very specific conditions) to evaluate their therapeutic effects in 6 voluntary SARS and COVID-19 infected persons with an integrative diagnosis by a computational Mora®Nova apparatus to access the basal and experimental human physiological parameters.

Conditions

• Coronavirus Infections
• Coronavirus Sars-Associated
• SARS (Severe Acute Respiratory Syndrome)
• COVID-19

Interventions

BIOLOGICAL

Marine liquid and fluids

Marine liquid and fluids extracted from freshwater bivalve of A. cygnea (under very specific conditions)

BIOLOGICAL

Impregnation

SARS / COVID-19 fluid/liquid - impregnation

BIOLOGICAL

Incubation

SARS / COVID-19 fluid-bivalve-incubation

BIOLOGICAL

Manipulation

Bivalve Manipulation - Stress inducing

BIOLOGICAL

Refrigeration

Refrigerated fluid to check for maintained response

Sponsors & Collaborators

• Instituto Politécnico de Bragança

  collaborator OTHER

• Universidade do Porto

  lead OTHER

Principal Investigators

• Jorge P Machado, PhD · ICBAS - Instituto de Ciências Biomédicas Abel Salazar

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

CROSSOVER

Eligibility

Min Age

14 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2021-10-01

Primary Completion

2022-10-31

Completion

2022-11-30

Countries

• Portugal

Study Locations