RVU120 (SEL120) in Patients with Relapse/Refractory Metastatic or Advanced Solid Tumors
NCT05052255 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 120
Last updated 2024-12-17
Summary
This is a phase 1/2, dose-escalation and expansion study investigating the safety, pharmacokinetics, and efficacy of RVU120 (SEL120) in patients with metastatic or advanced solid tumors progressing from previous lines of therapy.
Conditions
- Advanced Solid Tumor
Interventions
- DRUG
-
RVU120
RVU120 will be administered as a single oral dose every other day over a 3 week treatment cycle until disease progression or unacceptable toxicity and an alternative daily dosing schedule will also be tested.
Sponsors & Collaborators
-
Ryvu Therapeutics SA
lead INDUSTRY
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2021-08-13
- Primary Completion
- 2025-05-31
- Completion
- 2025-05-31
Countries
- Poland
- Spain
Study Locations
More Related Trials
-
A Dose Escalation and Expansion Study of [177Lu]Lu-SN201 in Participants With Advanced Cancer
NCT06184035 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
First-in-Human Study of MS201408-0005A as Single Agent and in Combinations
NCT03306420 ·Status: TERMINATED ·Phase: PHASE1
-
A Phase 1 Study of ARQ 197 in Patients With Solid Tumors
NCT00609921 ·Status: COMPLETED ·Phase: PHASE1
-
Study of Intravenous RXDX-107 in Patients With Solid Tumors
NCT02548390 ·Status: TERMINATED ·Phase: PHASE1
-
A First-in-Human Dose Escalation and Expansion Study to Evaluate Intratumoral Administration of SAR441000 as Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors
NCT03871348 ·Status: TERMINATED ·Phase: PHASE1
-
A Study Evaluating Safety and Therapeutic Activity of ANV419 in Patients with Advanced Cancer.
NCT04855929 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of YL242 in Subjects With Advanced Solid Tumors
NCT07197827 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
First-in-human Single Agent Study of SAR442257 in RRMM and RR-NHL
NCT04401020 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Weekly BI 836880 in Patients With Advanced Solid Tumors
NCT02689505 ·Status: COMPLETED ·Phase: PHASE1
-
Phase 1-2 Study of ASTX660 in Subjects With Advanced Solid Tumors and Lymphomas
NCT02503423 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
Study of PHA-848125AC in Adult Patients With Advanced/Metastatic Solid Tumors
NCT01300468 ·Status: COMPLETED ·Phase: PHASE1
-
Study to Determine the Safety, Tolerability, Pharmacokinetics and Recommended Phase 2 Dose (RP2D) of Livmoniplimab (ABBV-151) as a Single Agent and in Combination With Budigalimab (ABBV-181) in Participants With Locally Advanced or Metastatic Solid Tumors
NCT03821935 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
A Dose-escalation, Dose-finding, and Expansion Study of XL495 in Participants With Locally Advanced or Metastatic Solid Tumors
NCT06630247 ·Status: TERMINATED ·Phase: PHASE1
-
Study of CC-122 to Evaluate the Safety, Tolerability, and Effectiveness for Patients With Advanced Solid Tumors, Non-Hodgkin's Lymphoma, or Multiple Myeloma
NCT01421524 ·Status: COMPLETED ·Phase: PHASE1
-
Dose-Escalation Study of PHA-793887 in Patients With Advanced/Metastatic Solid Tumors
NCT00996255 ·Status: TERMINATED ·Phase: PHASE1
-
Safety and Efficacy of LAG525 Single Agent and in Combination With PDR001 in Patients With Advanced Malignancies.
NCT02460224 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study of RO5429083 in Patients With Metastatic and/or Locally Advanced, CD44-Expressing, Malignant Solid Tumors
NCT01358903 ·Status: COMPLETED ·Phase: PHASE1
-
An Open-Label Dose-Escalation Study to Evaluate XmAb24306 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors
NCT04250155 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
A Study to Investigate the Disposition of Radio-labeled AVE8062 Compound Administered as a 30-minute IV Infusion to Patients With Advanced Solid Tumor
NCT01063946 ·Status: COMPLETED ·Phase: PHASE1
-
Study of FF-10502-01 in Patients With Advanced Solid Tumors and Lymphomas
NCT02661542 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Dose Escalation of RMC-4630 Monotherapy in Relapsed/Refractory Solid Tumors
NCT03634982 ·Status: UNKNOWN ·Phase: PHASE1
-
Phase I Study VG2025 as a Single Agent and in Combination Therapy With Nivolumab in Subjects With Advanced Malignant Solid Tumors
NCT05266612 ·Status: RECRUITING ·Phase: PHASE1
-
Safety Study of AMG 228 to Treat Solid Tumors
NCT02437916 ·Status: TERMINATED ·Phase: PHASE1
-
A Study Exploring the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB086550 in Participants With Advanced Solid Tumors
NCT03762447 ·Status: COMPLETED ·Phase: PHASE1
-
A Study Evaluating The Safety And Pharmacokinetics Of Escalating Doses Of RO7297089 In Patients With Relapsed Or Refractory Multiple Myeloma
NCT04434469 ·Status: COMPLETED ·Phase: PHASE1