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Interaction of Muscle Dystrophy, Glucose Metabolism and Insulin Sensitivity

NCT05052073 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2021-09-22

No results posted yet for this study

Summary

The aim of this project to characterize systemic and organ-specific (subcutaneous adipose tissue and skeletal muscle) metabolic responses at rest and during standardized, moderate exercise after an oral glucose load in patients with various geneticaly heritable foms of skeletal muscle dystrophies. Metabolic responses will be monitored by indirect calorimetry (canopy and/or metabolic chamber at rest and during exercise) and microdialysis (adipose tissue and skeletal muscle at rest) before and after an oral glucose load (75 g).

Conditions

  • Various Forms of Skeletal Muscle Dystrophy

Interventions

DIAGNOSTIC_TEST

oral glucose load at rest

oral glucose load (75 g) after an 12h overnight fast at rest accompanied by blood sampling and dialysate sampling (adipose tissue and skeletal muscle), and calorimetry (canopy) over three hours.

DIAGNOSTIC_TEST

oral glucose load and exercise

oral glucose load (75 g) after an 12h overnight fast followed by a defined (0.5 W / kg), moderate bicycle exercise i a metabolic chamber

Sponsors & Collaborators

  • Charite University, Berlin, Germany

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2009-09-01
Primary Completion
2022-06-30
Completion
2022-12-31

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05052073 on ClinicalTrials.gov