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Comparison of the Concentration of Estrogen and Testosterone Ratio in Male Patients With Cirrhosis and Hypotension

NCT05051293 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2026-03-24

No results posted yet for this study

Summary

Cirrhosis is an end stage in liver disease leading to replacement of normal liver tissue with regenerative nodules surrounded by fibrous bands in response to chronic liver injury. It is the eighth leading cause of death in the United States and the thirteenth leading cause of death globally. Patients with cirrhosis have decreased spontaneous vascular resistance leading to hypotension. The mechanism of hypotension in cirrhosis is thought to be a complex result of the presence of increased level of circulating vasodilators such a nitric oxide coupled with reduced resistance to vasoconstrictors and increased sensitivity to vasodilators.

Conditions

Interventions

OTHER

serum concentration of estrogen (E1 and E2) and testosterone ratio measurement

To measure the serum concentration of estrogen (E1 and E2) and testosterone ratio in all male cirrhosis patients

Sponsors & Collaborators

  • Methodist Health System

    lead OTHER

Principal Investigators

  • Mangesh Pagadala, MD · Methodist

Eligibility

Min Age
18 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-08-22
Primary Completion
2022-08-17
Completion
2024-08-17

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05051293 on ClinicalTrials.gov