MedTrace Logo

COVID-19: A Scope Research on Epidemiology and Clinical Course

NCT05046769 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 5000

Last updated 2021-09-16

No results posted yet for this study

Summary

Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV) 2 infection and the associated coronavirus disease 2019 (COVID-19) are the most recent international health threat challenging our ability to protect populations, to avoid severe outcomes and to understand both the population dynamics of this new condition and the breath of individual responses. Gathering information on the clinical course of the disease and the risk of transmission is essential to design effective therapeutic solutions and preventive measures. The aim of the study proposed, to be carried out at University Hospital Center of "São João" (CHUSJ), is to recruit and follow-up a cohort of patients diagnosed with SARS-CoV-2 infection, to evaluate the clinical course of SARS-CoV-2 infection and COVID-19 cases, to identify prognostic factors and to measure the risk of reinfection. Additionally, researchers intend to characterize the patients and household contacts to describe the dynamics of infection, to calculate household infection attack rate, and to perform the genetic sequencing of SARS-CoV-2 to understand determinants of disease course (namely long-term effects) and risk of household transmission. A sample of participants, identified during the process of evaluation of symptomatic individuals, at the same institution, and negative for SARS-CoV-2 will be selected as negative controls.

Participants will be consecutively recruited and the study is expected to enroll patients as long as the pandemic remains. Information will be gathered based on clinical individual charts, hospital data-bases (example: for administrative data) and individual computer assisted interviews to be performed at pre-defined intervals (3, 12 and 24 months) or according to clinical needs.

The project was approved by the local Ethical Committee and the Data Protection relevant authorities.

Conditions

  • Covid19
  • SARS CoV 2 Infection
  • Sequelae of; Infection

Sponsors & Collaborators

  • Centro Hospitalar De São João, E.P.E.

    collaborator OTHER

  • IPATIMUP - Instituto De Patologia E Imunologia Molecular Da Universidade Do Porto

    collaborator OTHER

  • Instituto de Saude Publica da Universidade do Porto

    lead OTHER

Principal Investigators

  • Margarida Tavares, MD, MPH · Centro Hospitalar Universitário São João & ISPUP

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-04-28
Primary Completion
2023-12-31
Completion
2025-12-31

Countries

  • Portugal

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05046769 on ClinicalTrials.gov