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The Effect of Cigarette Smoke on Sleep Quality and Physical Activity in People With Multiple Sclerosis

NCT05046535 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 72

Last updated 2024-06-14

No results posted yet for this study

Summary

Current evidence suggests that cigarette smoke increases disease progression in people with multiple sclerosis (PwMS) and worsen their symptoms. 70% of PwMS report sleep disturbances that negatively affects their quality of life. Cigarette smoke has been found to be associated with sleep disturbances in healthy adult smokers, but this relationship is unknown in PwMS. Also, those who smoke cigarettes have less physical endurance resulting in undesirable effects on physical activity. Also, current evidence suggests that genes play a major role in smoking behavior and that certain genetic differences greatly affects nicotine dependence. To our knowledge, this was never explored before among PwMS.

This study aims to explore the association between cigarette smoke, sleep quality, and physical activity in PwMS. Another aim is to explore the genetic susceptibility of people with MS to cigarette smoke, specifically to nicotine dependence

Conditions

Interventions

BEHAVIORAL

Sleep quality and physical activity

Self-reported assessments will be used to measure the following: overall sleep quality, insomnia symptoms, Obstructive sleep apnea. Physical activity will be measured objectively using the 6MWT, 9HPT, and cardiorespiratory fitness using the VO2 submaximal test on the recumbent stepper.

GENETIC

Nicotine dependence

DNA sequencing for 20-25 subjects out of the whole sample will be performed. Sanger sequencing to all subjects will also be performed to identify related genes

DIAGNOSTIC_TEST

Nicotine and cotinine serum levels

Cotinine serum level which is a major metabolite of nicotine and the preferred biomarker for measuring tobacco use will be measured together with nicotine levels using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).

BEHAVIORAL

Smoking

Surveys that measure nicotine dependence and smoking behavior

Sponsors & Collaborators

  • University of Jordan

    lead OTHER

Principal Investigators

  • Mayis Aldughmi, PhD · University of Jordan

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-09-01
Primary Completion
2024-02-01
Completion
2024-06-01

Countries

  • Jordan

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05046535 on ClinicalTrials.gov