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Backtracking Leukemia-Typical Somatic Mutations in Cord Blood

NCT05014165 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 300

Last updated 2026-04-08

No results posted yet for this study

Summary

A comprehensive mechanistic and epidemiological study to obtain banked cord blood samples from consecutive childhood leukemia patients enrolled in the COG Project:EveryChild (APEC14B1) study. Will attempt to backtrack the initiating genomic alteration identified in the matched diagnostic leukemia sample and molecularly characterize pre-leukemic cells. The ultimate goal of this research is to pinpoint the cell of origin of leukemogenic alterations formed in utero, elucidating the etiology of these initiating mutations (as opposed to frank leukemia), and devising a test for circulating pre-leukemia that can be applied on a population-wide basis.

Conditions

Interventions

OTHER

Cord blood Sample Collection

Obtain banked cord blood samples from consecutive childhood leukemia patients

OTHER

Case identification and recruitment

Cases meeting eligibility and who have given consent through APEC14B1 for future contact for non-therapeutic studies

OTHER

Questionnaire Administration

The family will be given an option to complete questionnaire on paper, online, or over the telephone.

Sponsors & Collaborators

  • National Cancer Institute (NCI)

    collaborator NIH

  • Children's Oncology Group

    lead NETWORK

Principal Investigators

  • Adam de Smith, PhD · Beckman Research Institute of the City of Hope

  • Logan Spector, PhD · University of Minnesota Masonic Cancer Center

Eligibility

Max Age
25 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-08-25
Primary Completion
2026-09-30
Completion
2026-09-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05014165 on ClinicalTrials.gov