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Mapping of Cardiac Power in Healthy Humans and Testing of a New Blood Pressure Sensor

NCT05008133 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 25

Last updated 2022-04-01

No results posted yet for this study

Summary

Brief Summary:

The study will record hemodynamic data from 20 healthy volunteers at rest and during moderate bicycle exercise in the recumbent and half sitting position for the following purposes:

Sub-study 1 Testing the overall accuracy and the dependence on changes in posture and exercise of a new non-invasive blood pressure sensor against simultaneous invasive measurements.

Sub-study 2 Exploration of the effect of exercise and position on cardiac energy delivery to the circulation. The interplay between heart and vasculature (Ventriculo-arterial coupling) will be characterized based on simultaneous blood pressure and ultrasound blood flow measurements.

Sub-study 3 Evaluation and possible improvement of an individualized mechanistic model predicting the hemodynamic response to exercise based on hemodynamic profile at rest.

Sub-study 4 Testing of a machine learning based system for evaluation of dynamic autoregulation of renal blood flow from simultaneous continuous blood pressure and ultrasound blood flow measurements.

Conditions

  • Healthy Volunteers

Interventions

BEHAVIORAL

Bicycle exercise

Stepwise increased exercise for 5 minutes at 0, 50, 100 and 150 Watts. One series lying flat in prone position, after 15 minutes of rest, series repeated at 70 degrees head up tilt.

Sponsors & Collaborators

  • St. Olavs Hospital

    collaborator OTHER

  • Norwegian University of Science and Technology

    lead OTHER

Principal Investigators

  • Idar Kirkeby-Garstad, Md, PhD · Dept of Anesthesia and Intensive Care, St Olavs Hospital

  • Hilde Pleym, MD PhD · Dept of Anesthesia and Intensive Care, St Olavs Hospital

  • Øystein Risa · NTNU, Department of Circulation and Imaging

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-05-14
Primary Completion
2021-11-04
Completion
2021-11-04

Countries

  • Norway

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05008133 on ClinicalTrials.gov