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Interaction Between Air Pollution, Pollens and Allergic Rhinitis

NCT05007327 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 1215

Last updated 2023-10-19

No results posted yet for this study

Summary

Seasonal allergic rhinitis has multiple consequences: sleep disturbances, fatigue, depressed mood, impaired quality of life and productivity, and co-morbid conditions such as asthma, which affects one third of AR patients.

In Europe, more than 150 million people suffer from allergic rhinitis and more than 25 million suffer from asthma. About 30% have uncontrolled rhinitis during exposure to allergens. The impact of allergic diseases on work productivity is estimated to be between 30 and 50 billion € per year in the EU.

Studies show that pollution can play a role in the amplification of the response to inhaled pollen allergens by inducing morphological and functional modifications of nasal and bronchial epithelia, but also by inducing structural modifications of allergenic molecules. However, although data show that the symptoms of AR are aggravated by exposure to air pollution, this effect is not observed for all pollens.

The study area is very exposed to pollens (with a significant presence of cypress pollen) and air pollution, and presents a prevalence of asthma of 17% while the national average is about 7%.

The aim of this study is to establish, if they exist, links between pollens of various species, air pollution and symptoms of allergic rhinitis. The knowledge of these links will allow public authorities to set up prevention actions, and patients to better manage their allergic rhinitis on a daily basis.

Conditions

  • Allergic Rhinitis Due to Pollen
  • Allergic Rhinitis With Asthma

Interventions

OTHER

Exposure to pollen and air pollution

For all subjects of the cohort, we will follow exposure to pollen and air pollution.

Sponsors & Collaborators

  • MASK-air SAS

    lead INDUSTRY

Principal Investigators

  • Denis Charpin, Prof · Association pour la Prévention de la Pollution Atmosphérique

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-06-22
Primary Completion
2022-06-30
Completion
2022-06-30

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05007327 on ClinicalTrials.gov