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Comparison Neuromuscular Blockade Monitors

NCT05006807 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2023-09-21

No results posted yet for this study

Summary

The overall objective of this research is to evaluate different laboratory-built and commercially available sensors used to measure the effects of neuromuscular blocking drugs on neuromuscular function during surgery, by measuring evoked thumb twitch response to ulnar nerve stimulation (also known as "twitch monitoring"). The specific aim is to compare mechanomyography, which is the "gold standard" laboratory measurement to assess neuromuscular blockade, to the sensors used in commercially available neuromuscular blockade monitors, such as acceleromyography and electromyography. The study endpoints are the train-of-four count (TOFC), the ratio of the height of the 4th twitch to the height of the 1st twitch (train-of-four ratio, TOFR), and the post tetanic count (PTC). The mechanomyography devices have been constructed in our laboratory and are not commercially available.

Conditions

  • Neuromuscular Blockade

Interventions

DEVICE

Mechanomyograph Twitch Monitor

Measurement of train-of-four count and ratio and post tetanic count

DEVICE

Stimpod Twitch Monitor

Measurement of train-of-four count and ratio and post tetanic count

DEVICE

TetraGraph Twitch Monitor

Measurement of train-of-four count and ratio and post titanic count

DEVICE

TwitchView Twitch Monitor

Measurement of train-of-four count and ratio and post tetanic count

DEVICE

Nihon Kohden Twitch Monitor

Measurement of train-of-four count and ratio and post tetanic count

OTHER

Palpation of twitch count

The train-of-four count is determined by manual palpation of the evoked twitch response

Sponsors & Collaborators

Principal Investigators

  • T. Andrew Bowdle, MD, PhD · University of Washington

Eligibility

Min Age
18 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-02-01
Primary Completion
2024-06-30
Completion
2024-06-30

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05006807 on ClinicalTrials.gov