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Comparison of Transbronchial Cryobiopsy and Forceps Biopsy in Lung Transplant Recipients

NCT05006742 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2024-06-28

No results posted yet for this study

Summary

CLAD is defined as loss of lung function after other factors, particularly infections have been excluded. Readily accessible diagnostic procedures to detect acute cellular rejection at the earliest possible occasion is crucial for posttransplant survival. Serial lung function tests, laboratory testing and pulmonary imaging are only clinical indicators of chronic allograft dysfunction in lung transplant recipients. Since forceps biopsy to detect acute cellular rejection in lung transplant recipients has several shortcomings, the purpose of this study is to investigate a new biopsy technique using the transbronchial cryoprobe.

Conditions

  • Lung Transplant Rejection
  • Lung Transplant Failure and Rejection

Interventions

PROCEDURE

CB study arm

Included patients are randomized to receive cryobiopsy

PROCEDURE

FB-CB study arm

Included patients are randomized to receive forceps biopsy and cryobiopsy within the same session

Sponsors & Collaborators

  • University of Zurich

    lead OTHER

Principal Investigators

  • Carolin Steinack · University of Zurich

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-05-07
Primary Completion
2024-01-31
Completion
2024-02-28

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05006742 on ClinicalTrials.gov