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Impact of Chemotherapy on Urinary Biomarkers and Non-Invasive Urodynamics in Children

NCT04993859 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 152

Last updated 2025-10-15

No results posted yet for this study

Summary

The over-arching aim of this study is to evaluate the effects of two specific anti-cancer chemotherapies, vincristine and doxorubicin, on bladder function and urine composition.

Conditions

  • Survivors of Childhood Cancer
  • Bladder Dysfunction

Interventions

DIAGNOSTIC_TEST

Non-invasive Urodynamic Test (niUDS)

A noninvasive urodynamics is a simple test used to evaluate urinary flow.

DIAGNOSTIC_TEST

Urinary proteomic screen

Urine proteomics is a powerful platform to identify urinary excreted proteins and peptides in different stages of disease or therapy and to determine their quantity, functions, and interaction.

OTHER

Dysfunctional Voiding Symptom Score Survey (DVSS)

The Dysfunctional Voiding Symptom Score provides accurate and objective grading of voiding behaviors of children.

Sponsors & Collaborators

  • National Cancer Institute (NCI)

    collaborator NIH

  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    collaborator NIH

  • Children's Hospital Colorado

    collaborator OTHER

  • University of Colorado, Denver

    lead OTHER

Principal Investigators

  • Nicholas Cost, MD · Children's Hospital Colorado

Eligibility

Min Age
5 Years
Max Age
13 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-06-02
Primary Completion
2026-07-09
Completion
2026-07-09

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04993859 on ClinicalTrials.gov