Trial Outcomes & Findings for Peer PrEP Referral + HIV Self-test Delivery for PrEP Initiation in Kenya (NCT NCT04982250)

To identify index peers for recruitment, we reviewed the records of public clinics and research programs delivering PrEP in the region and called adolescent girls and young women (AGYW) who met the study eligibility criteria. Referred peers were recruited by index peers, who were given instructions to only recruit peers between 16 to 24 years who they thought might benefit from PrEP.

In both the pilot and the 2-arm cRCT, index peers (k) referred their peers to HIV services (i.e., referred peers, n). At follow-up, index peers reported outcomes for all the referred peers (started). At follow up, some of the referred peers were also enrolled (completed). Thus, some outcomes are measured among index peers, referred peers who started (as reported by index peers), and referred peers who completed (as reported by referred peers). Enrollment totals reflect those who completed.

Peer PrEP Referral + HIV Self-test Delivery for PrEP Initiation in Kenya

Number of referred peers that initiated PrEP, among all referred peers, as reported by index peers.

Number of referred peers that initiated PrEP, among all eligible referred peers, as reported by index peers.

Number of referred peers that initiated PrEP, among eligible referred peers who enrolled and completed follow-up, as reported by referred peers.

Number of referred peers referred to PrEP, among all referred peers, as reported by index peers.

Number of referred peers that used HIVST, among referred peers who enrolled and completed follow-up, as reported by referred peers.

Number of referred peers who tested for HIV (any form, including HIVST) since peer PrEP referral, among all referred peers, as reported by index peers.

Number of referred peers that returned to a clinic to refill PrEP since referral, among all referred peers, as reported by index peers.

Number of index peers that returned to a clinic to refill PrEP in the past 3 months.

A 0-100 point PrEP adherence score derived from the validated three-item Wilson et al Adherence scale with higher scores indicating higher adherence, among referred peers who enrolled and completed follow-up, as reported by referred peers.

Median number of referred peers referred to PrEP services by each index peer.

Number of referred peers in the enhanced group that used HIVST, among referred peers in the enhanced group who enrolled and completed follow-up, as reported by referred peers in the enhanced group.

Number of referred peers that went to a clinic to access HIV prevention or treatment services, among referred peers who enrolled and completed follow-up, as reported by referred peers.

Number of referred peers that received the intervention or standard-of-care materials, among referred peers who enrolled and completed follow-up, as reported by referred peers.

Number of referred peers and index peers who agree/strongly agree (on a 5-point Likert scale) to statements adapted from the Theoretical Framework of Acceptability.

Number of referred peers and index peers who agree/strongly agree (on a 5-point Likert scale) to statements adapted from the Appropriateness of Intervention Measure instrument.

Normal of referred peers and index peers who agree/strongly agree (on a 5-point Likert scale) to statements adapted from the Feasibility of Intervention Measure instrument.