MedTrace Logo

Pulmonary Assessment in Thoracic Insufficiency Syndrome Patients

NCT04977830 · Status: WITHDRAWN · Phase: NA · Type: INTERVENTIONAL

Last updated 2026-03-05

No results posted yet for this study

Summary

Thoracic insufficiency syndrome (TIS) is a complex condition that involves chest wall deformities that can affect normal breathing and lung growth. In most cases, children with TIS are also born with spine disorders such as scoliosis. The inability of the thorax to support normal respiration or lung growth can cause respiratory distress and even mortality. Investigators aim to validate MRI imaging sequences to use as an assessment tool for pulmonary function.

Conditions

  • Thoracic Insufficiency Syndrome

Interventions

DEVICE

Xenon-129

Patients will undergo a hyperpolarized MRI with administered Xenon gas

Sponsors & Collaborators

  • Xemed LLC

    collaborator INDUSTRY

  • Patrick Cahill, MD

    lead OTHER

Principal Investigators

  • Patrick Cahill, MD · Children's Hopsital of Philadelphia

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
6 Years
Max Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-01-31
Primary Completion
2026-08-30
Completion
2026-08-30
FDA Device
Yes

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04977830 on ClinicalTrials.gov