Trial Outcomes & Findings for Cognitive Reappraisal Training for Borderline Personality (NCT NCT04967222)
NCT ID: NCT04967222
Last Updated: 2025-08-05
Results Overview
BOLD signal change in Picture Induced Negative Emotion Signature (PINES) network activity that includes the amygdala, insula, and other regions by measuring neural activation using fMRI.
COMPLETED
NA
60 participants
Baseline and up to 6 weeks of treatment
2025-08-05
Participant Flow
60 participants consented. After preliminary screening visits, 26 participants were randomized.
Participant milestones
| Measure |
All Participants Consented
All participants consented and had screening visit
|
Cognitive Reappraisal-by-Distancing (CRD)
Subjects will be coached to use cognitive reappraisal-by-distancing to downregulate their negative reactions to aversive emotional pictures using practice pictures.
Cognitive Reappraisal by Distancing: Reappraisal-by-distancing treatment. Participants meet 2 times a week for 6 weeks to learn reappraisal by distancing through repeated practice with negative emotional pictures. The therapist will help model and shape the technique.
|
Control Downregulate Condition (CD)
Subjects will be coached to practice their customary emotion regulatory techniques in a treatment occurring twice a week for 6 weeks.
Control Downregulate Condition: Participants either meet 2x a week for 6- weeks to gain added practice, under the guidance of a therapist, using their customary emotion regulatory strategies to downregulate their negative reactions to aversive pictures.
|
|---|---|---|---|
|
Screening Visits
STARTED
|
60
|
0
|
0
|
|
Screening Visits
COMPLETED
|
26
|
0
|
0
|
|
Screening Visits
NOT COMPLETED
|
34
|
0
|
0
|
|
Randomized
STARTED
|
0
|
13
|
13
|
|
Randomized
COMPLETED
|
0
|
10
|
9
|
|
Randomized
NOT COMPLETED
|
0
|
3
|
4
|
Reasons for withdrawal
| Measure |
All Participants Consented
All participants consented and had screening visit
|
Cognitive Reappraisal-by-Distancing (CRD)
Subjects will be coached to use cognitive reappraisal-by-distancing to downregulate their negative reactions to aversive emotional pictures using practice pictures.
Cognitive Reappraisal by Distancing: Reappraisal-by-distancing treatment. Participants meet 2 times a week for 6 weeks to learn reappraisal by distancing through repeated practice with negative emotional pictures. The therapist will help model and shape the technique.
|
Control Downregulate Condition (CD)
Subjects will be coached to practice their customary emotion regulatory techniques in a treatment occurring twice a week for 6 weeks.
Control Downregulate Condition: Participants either meet 2x a week for 6- weeks to gain added practice, under the guidance of a therapist, using their customary emotion regulatory strategies to downregulate their negative reactions to aversive pictures.
|
|---|---|---|---|
|
Randomized
Lost to Follow-up
|
0
|
1
|
1
|
|
Randomized
Physician Decision
|
0
|
0
|
1
|
|
Randomized
Withdrawal by Subject
|
0
|
0
|
2
|
|
Randomized
abnormal finding in MRI
|
0
|
2
|
0
|
Baseline Characteristics
Cognitive Reappraisal Training for Borderline Personality
Baseline characteristics by cohort
| Measure |
Cognitive Reappraisal-by-Distancing (CRD)
n=13 Participants
Subjects will be coached to use cognitive reappraisal-by-distancing to downregulate their negative reactions to aversive emotional pictures using practice pictures.
Cognitive Reappraisal by Distancing: Reappraisal-by-distancing treatment. Participants meet 2 times a week for 6 weeks to learn reappraisal by distancing through repeated practice with negative emotional pictures. The therapist will help model and shape the technique.
|
Control Downregulate Condition (CD)
n=13 Participants
Subjects will be coached to practice their customary emotion regulatory techniques in a treatment occurring twice a week for 6 weeks.
Control Downregulate Condition: Participants either meet 2x a week for 6- weeks to gain added practice, under the guidance of a therapist, using their customary emotion regulatory strategies to downregulate their negative reactions to aversive pictures.
|
Total
n=26 Participants
Total of all reporting groups
|
|---|---|---|---|
|
Age, Continuous
|
31.08 years
STANDARD_DEVIATION 8.14 • n=99 Participants
|
30.46 years
STANDARD_DEVIATION 9.22 • n=107 Participants
|
30.77 years
STANDARD_DEVIATION 8.52 • n=206 Participants
|
|
Sex: Female, Male
Female
|
12 Participants
n=99 Participants
|
12 Participants
n=107 Participants
|
24 Participants
n=206 Participants
|
|
Sex: Female, Male
Male
|
1 Participants
n=99 Participants
|
1 Participants
n=107 Participants
|
2 Participants
n=206 Participants
|
|
Ethnicity (NIH/OMB)
Hispanic or Latino
|
1 Participants
n=99 Participants
|
2 Participants
n=107 Participants
|
3 Participants
n=206 Participants
|
|
Ethnicity (NIH/OMB)
Not Hispanic or Latino
|
12 Participants
n=99 Participants
|
11 Participants
n=107 Participants
|
23 Participants
n=206 Participants
|
|
Ethnicity (NIH/OMB)
Unknown or Not Reported
|
0 Participants
n=99 Participants
|
0 Participants
n=107 Participants
|
0 Participants
n=206 Participants
|
|
Race (NIH/OMB)
American Indian or Alaska Native
|
0 Participants
n=99 Participants
|
0 Participants
n=107 Participants
|
0 Participants
n=206 Participants
|
|
Race (NIH/OMB)
Asian
|
4 Participants
n=99 Participants
|
2 Participants
n=107 Participants
|
6 Participants
n=206 Participants
|
|
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
|
0 Participants
n=99 Participants
|
0 Participants
n=107 Participants
|
0 Participants
n=206 Participants
|
|
Race (NIH/OMB)
Black or African American
|
0 Participants
n=99 Participants
|
2 Participants
n=107 Participants
|
2 Participants
n=206 Participants
|
|
Race (NIH/OMB)
White
|
6 Participants
n=99 Participants
|
8 Participants
n=107 Participants
|
14 Participants
n=206 Participants
|
|
Race (NIH/OMB)
More than one race
|
2 Participants
n=99 Participants
|
0 Participants
n=107 Participants
|
2 Participants
n=206 Participants
|
|
Race (NIH/OMB)
Unknown or Not Reported
|
1 Participants
n=99 Participants
|
1 Participants
n=107 Participants
|
2 Participants
n=206 Participants
|
PRIMARY outcome
Timeframe: Baseline and up to 6 weeks of treatmentPopulation: Data available for participants who had procedure
BOLD signal change in Picture Induced Negative Emotion Signature (PINES) network activity that includes the amygdala, insula, and other regions by measuring neural activation using fMRI.
Outcome measures
| Measure |
Cognitive Reappraisal-by-Distancing (CRD)
n=13 Participants
Subjects will be coached to use cognitive reappraisal-by-distancing to downregulate their negative reactions to aversive emotional pictures using practice pictures.
Cognitive Reappraisal by Distancing: Reappraisal-by-distancing treatment. Participants meet 2 times a week for 6 weeks to learn reappraisal by distancing through repeated practice with negative emotional pictures. The therapist will help model and shape the technique.
|
Control Downregulate Condition (CD)
n=13 Participants
Subjects will be coached to practice their customary emotion regulatory techniques in a treatment occurring twice a week for 6 weeks.
Control Downregulate Condition: Participants either meet 2x a week for 6- weeks to gain added practice, under the guidance of a therapist, using their customary emotion regulatory strategies to downregulate their negative reactions to aversive pictures.
|
|---|---|---|
|
Change in PINES Network Activity
baseline
|
0.15 BOLD Signal
Standard Deviation 0.04
|
0.14 BOLD Signal
Standard Deviation 0.03
|
|
Change in PINES Network Activity
after up to 6 weeks of treatment
|
0.12 BOLD Signal
Standard Deviation 0.04
|
012 BOLD Signal
Standard Deviation 0.06
|
PRIMARY outcome
Timeframe: Baseline and up to 6 weeks of treatmentPopulation: Data available for participants who completed instrument.
Zanarini Rating Scale for Borderline Personality, self-report. Full scale from 0-36. Higher score indicates poorer health outcomes.
Outcome measures
| Measure |
Cognitive Reappraisal-by-Distancing (CRD)
n=13 Participants
Subjects will be coached to use cognitive reappraisal-by-distancing to downregulate their negative reactions to aversive emotional pictures using practice pictures.
Cognitive Reappraisal by Distancing: Reappraisal-by-distancing treatment. Participants meet 2 times a week for 6 weeks to learn reappraisal by distancing through repeated practice with negative emotional pictures. The therapist will help model and shape the technique.
|
Control Downregulate Condition (CD)
n=13 Participants
Subjects will be coached to practice their customary emotion regulatory techniques in a treatment occurring twice a week for 6 weeks.
Control Downregulate Condition: Participants either meet 2x a week for 6- weeks to gain added practice, under the guidance of a therapist, using their customary emotion regulatory strategies to downregulate their negative reactions to aversive pictures.
|
|---|---|---|
|
Change in Zanarini Rating Scale for Borderline Personality (ZAN-BPD)
Baseline
|
15.22 score on a scale
Standard Deviation 7.70
|
12.86 score on a scale
Standard Deviation 5.70
|
|
Change in Zanarini Rating Scale for Borderline Personality (ZAN-BPD)
after up to 6 weeks of treatment
|
10 score on a scale
Standard Deviation 9.52
|
9.38 score on a scale
Standard Deviation 6.19
|
SECONDARY outcome
Timeframe: Baseline and at 2-,4-, and 6-weeksPopulation: Data available for participants who completed instrument.
There are three affective symptoms in the ZAN-BPD (with a sector score ranging from 0-12): inappropriate anger/frequent angry acts, mood instability, and chronic feelings of emptiness. There are two cognitive symptoms (with a sector score ranging from 0-8): stress-related paranoia/dissociation and severe identity disturbance. (Identity disturbance was placed in the cognitive realm because it is based on a series of false beliefs or overvalued ideas, such as that one is a bad person.) There are also two impulsive symptoms (with a sector score ranging from 0-8): self-mutilative/suicidal efforts and at least two other forms of impulsivity. Finally, there are two symptoms in the interpersonal realm of BPD (with a sector score ranging from 0-8): frantic efforts of avoid abandonment and intense, unstable relationships. The four sector scores sum to provide a total score of borderline psychopathology, which ranges from 0-36. Higher score indicates poorer health outcomes
Outcome measures
| Measure |
Cognitive Reappraisal-by-Distancing (CRD)
n=13 Participants
Subjects will be coached to use cognitive reappraisal-by-distancing to downregulate their negative reactions to aversive emotional pictures using practice pictures.
Cognitive Reappraisal by Distancing: Reappraisal-by-distancing treatment. Participants meet 2 times a week for 6 weeks to learn reappraisal by distancing through repeated practice with negative emotional pictures. The therapist will help model and shape the technique.
|
Control Downregulate Condition (CD)
n=13 Participants
Subjects will be coached to practice their customary emotion regulatory techniques in a treatment occurring twice a week for 6 weeks.
Control Downregulate Condition: Participants either meet 2x a week for 6- weeks to gain added practice, under the guidance of a therapist, using their customary emotion regulatory strategies to downregulate their negative reactions to aversive pictures.
|
|---|---|---|
|
Change in ZAN-BPD Sector Scores
Baseline - Affective Sector
|
5.33 score on a scale
Standard Deviation 2.29
|
5 score on a scale
Standard Deviation 2.83
|
|
Change in ZAN-BPD Sector Scores
Baseline - Cognitive Sector
|
4 score on a scale
Standard Deviation 2.45
|
2.71 score on a scale
Standard Deviation 1.80
|
|
Change in ZAN-BPD Sector Scores
Baseline - Impulsive Sector
|
1.89 score on a scale
Standard Deviation 1.83
|
2.57 score on a scale
Standard Deviation 1.40
|
|
Change in ZAN-BPD Sector Scores
Baseline - Interpersonal Sector
|
4 score on a scale
Standard Deviation 2.24
|
2.57 score on a scale
Standard Deviation 1.13
|
|
Change in ZAN-BPD Sector Scores
2 weeks - Affective Sector
|
4.3 score on a scale
Standard Deviation 3.13
|
4.5 score on a scale
Standard Deviation 2.42
|
|
Change in ZAN-BPD Sector Scores
2 weeks - Cognitive Sector
|
2.8 score on a scale
Standard Deviation 2.49
|
2.1 score on a scale
Standard Deviation 1.85
|
|
Change in ZAN-BPD Sector Scores
2 weeks - Impulsive Sector
|
1.9 score on a scale
Standard Deviation 1.91
|
1.3 score on a scale
Standard Deviation 0.82
|
|
Change in ZAN-BPD Sector Scores
2 weeks- Interpersonal Sector
|
2.5 score on a scale
Standard Deviation 2.37
|
2 score on a scale
Standard Deviation 1.63
|
|
Change in ZAN-BPD Sector Scores
4 weeks - Affective Sector
|
4 score on a scale
Standard Deviation 2.89
|
2.75 score on a scale
Standard Deviation 3.40
|
|
Change in ZAN-BPD Sector Scores
4 weeks - Cognitive Sector
|
2.57 score on a scale
Standard Deviation 2.76
|
1.75 score on a scale
Standard Deviation 1.71
|
|
Change in ZAN-BPD Sector Scores
4 weeks - Impulsive Sector
|
1.43 score on a scale
Standard Deviation 2.15
|
0.75 score on a scale
Standard Deviation 0.96
|
|
Change in ZAN-BPD Sector Scores
4 weeks - Interpersonal Sector
|
2.14 score on a scale
Standard Deviation 2.34
|
2.25 score on a scale
Standard Deviation 1.71
|
|
Change in ZAN-BPD Sector Scores
6 weeks - Affective Sector
|
3.5 score on a scale
Standard Deviation 3.42
|
4 score on a scale
Standard Deviation 2.20
|
|
Change in ZAN-BPD Sector Scores
6 weeks - Cognitive Sector
|
3.125 score on a scale
Standard Deviation 2.8
|
2.13 score on a scale
Standard Deviation 2.03
|
|
Change in ZAN-BPD Sector Scores
6 weeks - Impulsive Sector
|
1.38 score on a scale
Standard Deviation 2.00
|
1 score on a scale
Standard Deviation 1.07
|
|
Change in ZAN-BPD Sector Scores
6 weeks - Interpersonal Sector
|
2.38 score on a scale
Standard Deviation 2.50
|
2.5 score on a scale
Standard Deviation 2.40
|
SECONDARY outcome
Timeframe: Baseline and at 2-,4-, and 6-weeksPopulation: Data available for participants who completed instrument.
The Affective Lability Scale (ALS) consists of 54 items which are rated on a four-point Likert scale ranging from 0 ("very uncharacteristic of me") to 3 ("very characteristic of me"). Five of the items refer to shifts in anxiety/depression, eight refer to shifts in depression/elation, and the final five items concern shifts between anger and normal mood. The scale yields a total score of ALS, as well as subscores for the three affective domains. Total score range from 0 to 162, with higher score indicating more affective lability.
Outcome measures
| Measure |
Cognitive Reappraisal-by-Distancing (CRD)
n=13 Participants
Subjects will be coached to use cognitive reappraisal-by-distancing to downregulate their negative reactions to aversive emotional pictures using practice pictures.
Cognitive Reappraisal by Distancing: Reappraisal-by-distancing treatment. Participants meet 2 times a week for 6 weeks to learn reappraisal by distancing through repeated practice with negative emotional pictures. The therapist will help model and shape the technique.
|
Control Downregulate Condition (CD)
n=13 Participants
Subjects will be coached to practice their customary emotion regulatory techniques in a treatment occurring twice a week for 6 weeks.
Control Downregulate Condition: Participants either meet 2x a week for 6- weeks to gain added practice, under the guidance of a therapist, using their customary emotion regulatory strategies to downregulate their negative reactions to aversive pictures.
|
|---|---|---|
|
Change in Affective Lability Scale Total (ALS)
Baseline
|
95 score on a scale
Standard Deviation 25.52
|
104 score on a scale
Standard Deviation 17.29
|
|
Change in Affective Lability Scale Total (ALS)
2 weeks
|
82.91 score on a scale
Standard Deviation 26.11
|
93.27 score on a scale
Standard Deviation 16.75
|
|
Change in Affective Lability Scale Total (ALS)
4 weeks
|
74.3 score on a scale
Standard Deviation 32.67
|
85.8 score on a scale
Standard Deviation 23.01
|
|
Change in Affective Lability Scale Total (ALS)
6 weeks
|
80.7 score on a scale
Standard Deviation 38.21
|
87.11 score on a scale
Standard Deviation 16.17
|
SECONDARY outcome
Timeframe: Baseline and at 2-,4-, and 6-weeksPopulation: Data available for participants who completed instrument.
Perceive Stress Scale (PSS) - A 10-item questionnaire, each item scored 0 (never) to 4 (very often), full scale from 0-40, with higher score indicating higher perceived stress or the more often the person perceives stress.
Outcome measures
| Measure |
Cognitive Reappraisal-by-Distancing (CRD)
n=13 Participants
Subjects will be coached to use cognitive reappraisal-by-distancing to downregulate their negative reactions to aversive emotional pictures using practice pictures.
Cognitive Reappraisal by Distancing: Reappraisal-by-distancing treatment. Participants meet 2 times a week for 6 weeks to learn reappraisal by distancing through repeated practice with negative emotional pictures. The therapist will help model and shape the technique.
|
Control Downregulate Condition (CD)
n=13 Participants
Subjects will be coached to practice their customary emotion regulatory techniques in a treatment occurring twice a week for 6 weeks.
Control Downregulate Condition: Participants either meet 2x a week for 6- weeks to gain added practice, under the guidance of a therapist, using their customary emotion regulatory strategies to downregulate their negative reactions to aversive pictures.
|
|---|---|---|
|
Change in Perceived Stress Scale (PSS)
Baseline
|
2.28 score on a scale
Standard Deviation 0.34
|
2.36 score on a scale
Standard Deviation 0.33
|
|
Change in Perceived Stress Scale (PSS)
2 weeks
|
2.19 score on a scale
Standard Deviation 0.35
|
2.17 score on a scale
Standard Deviation 0.36
|
|
Change in Perceived Stress Scale (PSS)
4 weeks
|
2.22 score on a scale
Standard Deviation 0.35
|
2.28 score on a scale
Standard Deviation 0.25
|
|
Change in Perceived Stress Scale (PSS)
6 weeks
|
2.26 score on a scale
Standard Deviation 0.41
|
2.18 score on a scale
Standard Deviation 0.24
|
SECONDARY outcome
Timeframe: Baseline and at 2-,4-, and 6-weeksPopulation: Results available for participants who completed instrument
Difficulties in emotion regulation scale (DERS) The DERS is a 36-item self-report measure of six facets of emotion regulation. Items are rated on a scale of 1 (" almost never \[0-10%\] ") to 5 (" almost always \[91-100%\] "). Total scale from 6-216. Higher scores indicate more difficulty in emotion regulation.
Outcome measures
| Measure |
Cognitive Reappraisal-by-Distancing (CRD)
n=13 Participants
Subjects will be coached to use cognitive reappraisal-by-distancing to downregulate their negative reactions to aversive emotional pictures using practice pictures.
Cognitive Reappraisal by Distancing: Reappraisal-by-distancing treatment. Participants meet 2 times a week for 6 weeks to learn reappraisal by distancing through repeated practice with negative emotional pictures. The therapist will help model and shape the technique.
|
Control Downregulate Condition (CD)
n=13 Participants
Subjects will be coached to practice their customary emotion regulatory techniques in a treatment occurring twice a week for 6 weeks.
Control Downregulate Condition: Participants either meet 2x a week for 6- weeks to gain added practice, under the guidance of a therapist, using their customary emotion regulatory strategies to downregulate their negative reactions to aversive pictures.
|
|---|---|---|
|
Change in Difficulty in Emotion Regulation Scale Scores (DERS)
Baseline
|
119.15 score on a scale
Standard Deviation 13.85
|
126.58 score on a scale
Standard Deviation 19.66
|
|
Change in Difficulty in Emotion Regulation Scale Scores (DERS)
2 weeks
|
109.09 score on a scale
Standard Deviation 17.6
|
117.99 score on a scale
Standard Deviation 17.80
|
|
Change in Difficulty in Emotion Regulation Scale Scores (DERS)
4 weeks
|
110.2 score on a scale
Standard Deviation 22.64
|
112.70 score on a scale
Standard Deviation 30.67
|
|
Change in Difficulty in Emotion Regulation Scale Scores (DERS)
6 weeks
|
104.07 score on a scale
Standard Deviation 26.48
|
107.55 score on a scale
Standard Deviation 29.06
|
SECONDARY outcome
Timeframe: Baseline and at 2-,4-, and 6-weeksPopulation: Data for participants who completed instrument
The Beck Depression Inventory (BDI) is used to evaluate depression symptoms. This questionnaire is a 21-item, self-report rating inventory that measures characteristic attitudes and symptoms of depression. Scoring is from 0 (minimal) to 3 (severe), with total score from 0-63. Higher total scores indicate more severe depressive symptoms.
Outcome measures
| Measure |
Cognitive Reappraisal-by-Distancing (CRD)
n=13 Participants
Subjects will be coached to use cognitive reappraisal-by-distancing to downregulate their negative reactions to aversive emotional pictures using practice pictures.
Cognitive Reappraisal by Distancing: Reappraisal-by-distancing treatment. Participants meet 2 times a week for 6 weeks to learn reappraisal by distancing through repeated practice with negative emotional pictures. The therapist will help model and shape the technique.
|
Control Downregulate Condition (CD)
n=13 Participants
Subjects will be coached to practice their customary emotion regulatory techniques in a treatment occurring twice a week for 6 weeks.
Control Downregulate Condition: Participants either meet 2x a week for 6- weeks to gain added practice, under the guidance of a therapist, using their customary emotion regulatory strategies to downregulate their negative reactions to aversive pictures.
|
|---|---|---|
|
Change in Beck Depression Scale Score (BDI)
Baseline
|
24.62 score on a scale
Standard Deviation 9.45
|
20.08 score on a scale
Standard Deviation 7.66
|
|
Change in Beck Depression Scale Score (BDI)
2 weeks
|
22.09 score on a scale
Standard Deviation 10.55
|
15.36 score on a scale
Standard Deviation 9.52
|
|
Change in Beck Depression Scale Score (BDI)
4 weeks
|
22.3 score on a scale
Standard Deviation 14.02
|
16.3 score on a scale
Standard Deviation 11.91
|
|
Change in Beck Depression Scale Score (BDI)
6 weeks
|
18.7 score on a scale
Standard Deviation 13.26
|
16.67 score on a scale
Standard Deviation 12.22
|
SECONDARY outcome
Timeframe: Baseline and at 2-,4-, and 6-weeksPopulation: Data for participants who completed instrument.
A 40 self-report items questionnaire, each item scored on 4-point likert-type response scale from 1 (not at all) to 4 (almost always), full range from 40 to 160, with higher score suggesting higher levels of anxiety.4
Outcome measures
| Measure |
Cognitive Reappraisal-by-Distancing (CRD)
n=13 Participants
Subjects will be coached to use cognitive reappraisal-by-distancing to downregulate their negative reactions to aversive emotional pictures using practice pictures.
Cognitive Reappraisal by Distancing: Reappraisal-by-distancing treatment. Participants meet 2 times a week for 6 weeks to learn reappraisal by distancing through repeated practice with negative emotional pictures. The therapist will help model and shape the technique.
|
Control Downregulate Condition (CD)
n=13 Participants
Subjects will be coached to practice their customary emotion regulatory techniques in a treatment occurring twice a week for 6 weeks.
Control Downregulate Condition: Participants either meet 2x a week for 6- weeks to gain added practice, under the guidance of a therapist, using their customary emotion regulatory strategies to downregulate their negative reactions to aversive pictures.
|
|---|---|---|
|
Change in State-Trait Anxiety Scale Score (STAXI)
Baseline
|
84.54 score on a scale
Standard Deviation 7.89
|
90.5 score on a scale
Standard Deviation 8.72
|
|
Change in State-Trait Anxiety Scale Score (STAXI)
2 weeks
|
86.91 score on a scale
Standard Deviation 7.79
|
87.36 score on a scale
Standard Deviation 8.08
|
|
Change in State-Trait Anxiety Scale Score (STAXI)
4 weeks
|
90.9 score on a scale
Standard Deviation 7.45
|
91.5 score on a scale
Standard Deviation 9.41
|
|
Change in State-Trait Anxiety Scale Score (STAXI)
6 weeks
|
90.7 score on a scale
Standard Deviation 6.18
|
91.89 score on a scale
Standard Deviation 8.87
|
Adverse Events
Cognitive Reappraisal-by-Distancing (CRD)
Control Downregulate Condition (CD)
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Dr. Harold W Koenigsberg
Icahn School of Medicine at Mount Sinai
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place