Trial Outcomes & Findings for Angiotensin II for Distributive Shock (NCT NCT04904562)
NCT ID: NCT04904562
Last Updated: 2026-04-13
Results Overview
Total catecholamine dose for first 24 hours after distributive shock is first diagnosed
TERMINATED
PHASE4
2 participants
24 hours
2026-04-13
Participant Flow
Only 2 participants were enrolled in this study. Based on the low enrollment number, no data is reported here in order to protect and maintain participant privacy/confidentiality.
Participant milestones
| Measure |
Treatment
Angiotensin II administered as an intravenous (IV) infusion will be increased every 5 minutes by 5-10ng/kg/min increments up to 80ng/kg/min
Angiotensin II: Angiotensin II started at 5 ng/kg/min and titrated in 5-10 ng/kg/min increments every 5 minutes up to 80ng/kg/min to achieve target arterial pressure (MAP)
|
Control
Intravenous (IV) infusion (saline)
Placebo: Placebo
|
|---|---|---|
|
Overall Study
STARTED
|
1
|
1
|
|
Overall Study
COMPLETED
|
1
|
1
|
|
Overall Study
NOT COMPLETED
|
0
|
0
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Angiotensin II for Distributive Shock
Baseline characteristics by cohort
Baseline data not reported
PRIMARY outcome
Timeframe: 24 hoursPopulation: Only 2 participants were enrolled in this study. Based on the low enrollment number, no data is reported here in order to protect and maintain participant privacy/confidentiality.
Total catecholamine dose for first 24 hours after distributive shock is first diagnosed
Outcome measures
Outcome data not reported
SECONDARY outcome
Timeframe: 24 hoursPopulation: Only 2 participants were enrolled in this study. Based on the low enrollment number, no data is reported here in order to protect and maintain participant privacy/confidentiality.
Cumulative time spent with MAP \< 70 mmHg within the first 24 hours after distributive shock is first diagnosed
Outcome measures
Outcome data not reported
SECONDARY outcome
Timeframe: 24 hoursPopulation: Only 2 participants were enrolled in this study. Based on the low enrollment number, no data is reported here in order to protect and maintain participant privacy/confidentiality.
Time to extubation after arrival in the ICU if distributive shock is diagnosed intraoperatively or time to extubation after distributive shock is diagnosed postoperatively
Outcome measures
Outcome data not reported
SECONDARY outcome
Timeframe: 48 hoursPopulation: Only 2 participants were enrolled in this study. Based on the low enrollment number, no data is reported here in order to protect and maintain participant privacy/confidentiality.
Incidence of stroke confirmed by neurologist within 48 hours after distributive shock is first diagnosed
Outcome measures
Outcome data not reported
SECONDARY outcome
Timeframe: 48 hoursPopulation: Only 2 participants were enrolled in this study. Based on the low enrollment number, no data is reported here in order to protect and maintain participant privacy/confidentiality.
Incidence of acute kidney injury, staged by KDIGO Creatinine criteria, within 48 hours after distributive shock is first diagnosed
Outcome measures
Outcome data not reported
SECONDARY outcome
Timeframe: 24 hoursPopulation: Only 2 participants were enrolled in this study. Based on the low enrollment number, no data is reported here in order to protect and maintain participant privacy/confidentiality.
Incidence of new tachyarrhythmia within the first 24 hours after distributive shock is first diagnosed
Outcome measures
Outcome data not reported
SECONDARY outcome
Timeframe: 24 hoursPopulation: Only 2 participants were enrolled in this study. Based on the low enrollment number, no data is reported here in order to protect and maintain participant privacy/confidentiality.
Units of blood transfused within first 24 hours after distributive shock is first diagnosed
Outcome measures
Outcome data not reported
SECONDARY outcome
Timeframe: 24 hoursPopulation: Only 2 participants were enrolled in this study. Based on the low enrollment number, no data is reported here in order to protect and maintain participant privacy/confidentiality.
Fluid overload within the first 24 hours after distributive shock is first diagnosed
Outcome measures
Outcome data not reported
SECONDARY outcome
Timeframe: 1 yearPopulation: Only 2 participants were enrolled in this study. Based on the low enrollment number, no data is reported here in order to protect and maintain participant privacy/confidentiality.
Total time spent in the ICU after initial diagnosis of distributive shock
Outcome measures
Outcome data not reported
SECONDARY outcome
Timeframe: 1 yearPopulation: Only 2 participants were enrolled in this study. Based on the low enrollment number, no data is reported here in order to protect and maintain participant privacy/confidentiality.
Total time spent in the hospital after diagnosis of distributive shock
Outcome measures
Outcome data not reported
SECONDARY outcome
Timeframe: 30 daysPopulation: Only 2 participants were enrolled in this study. Based on the low enrollment number, no data is reported here in order to protect and maintain participant privacy/confidentiality.
Subject death within 30 days of diagnosis of distributive shock
Outcome measures
Outcome data not reported
Adverse Events
Treatment
Control
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place