MedTrace Logo

Identification of Novel Factors Leading to Activated Macrophage Expansion in COVID19 - INFLAME Study

NCT04903834 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 2000

Last updated 2021-05-27

No results posted yet for this study

Summary

This project aims to undertake a high-resolution analysis of previous cases of COVID19 infection to determine from all available clinical data recorded over the timeline of admission, who might benefit best from specific interventions designed to target a hyper inflammatory response in this condition. This approach offers a timely contribution to the field where the first phase of unselected clinical trials is already underway, and the second phase will require a more targeted approach. Southampton offers a unique opportunity to undertake this work, as it is widely accepted that the investigators lead the UK in clinical data informatics. This project links the investigators research efforts at the clinical level to current understanding of disease pathways, for which the investigators have effective interventions and the problem the investigators aim to solve is, who will benefit from the available novel anti-inflammatory approaches and when should this treatment be given?

Conditions

Interventions

DIAGNOSTIC_TEST

Soton hyperinflammation score

Score for hyperinflammation defined by blood parameters and other physiological measurements

DIAGNOSTIC_TEST

HScore

Score for secondary haemophagocytic lymphohistiocytosis validated in prior publications

Sponsors & Collaborators

  • University of Southampton

    collaborator OTHER

  • University Hospital Southampton NHS Foundation Trust

    lead OTHER

Principal Investigators

  • Michael R Ardern-Jones, DPhil FRCP · University of Southampton

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-06-30
Primary Completion
2024-06-24
Completion
2024-06-24

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04903834 on ClinicalTrials.gov