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Tobacco Use and the Risk of COVID-19

NCT04896918 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 450000

Last updated 2024-03-06

No results posted yet for this study

Summary

Contrasting hypotheses, including that of a protective role of nicotine, have been generated concerning the association between smoking and the occurrence of COVID-19 infection. The question has attracted a lively scientific and public debate. However, the studies conducted so far are based on clinical samples, with a majority of hospital case series, thus most likely suffering from bias due to selection.

The investigators propose to conduct an analysis of the potential causal association between smoking or the use of the Swedish smokeless tobacco snus and the occurrence of COVID-19 using data from a newly identified retrospective cohort in Sweden. Information on tobacco use will be extracted by public dental clinic records in Stockholm Region between October 2015 and January 2020. Information on diagnoses of COVID-19 will be obtained through record linkage with health care registers of inpatient and outpatient care during the period February 2020-August 2021. Socio-demographic information will be accrued from the register of the total population in Stockholm Region (Statistics Sweden). The risk of COVID-19 for tobacco users compared to non-tobacco users will be calculated as a measure of association adjusting for potential confounders.

Conditions

  • Covid19

Interventions

BEHAVIORAL

Tobacco use

Sponsors & Collaborators

  • Region Stockholm

    collaborator OTHER_GOV

  • Norforsk

    collaborator UNKNOWN

  • Norwegian Institute of Public Health

    collaborator OTHER_GOV

  • Finnish Institute for Health and Welfare

    collaborator OTHER_GOV

  • Karolinska Institutet

    lead OTHER

Principal Investigators

  • Maria Rosaria Galanti, PhD · Karolinska Institutet

Eligibility

Min Age
23 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-10-01
Primary Completion
2023-12-31
Completion
2023-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04896918 on ClinicalTrials.gov