Bronchopulmonary PK of AT-527 (R07496998)
NCT04877769 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 24
Last updated 2022-02-25
Summary
This study will assess the safety, tolerability and bronchopulmonary pharmacokinetics (PK) of AT-527 (R07496998)
Conditions
- Healthy Volunteer Study
Interventions
- DRUG
-
AT-527
administered twice daily (BID) for 2.5 days (5 doses in total)
Sponsors & Collaborators
- collaborator INDUSTRY
-
Atea Pharmaceuticals, Inc.
lead INDUSTRY
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SEQUENTIAL
Eligibility
- Min Age
- 18 Years
- Max Age
- 65 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2021-04-25
- Primary Completion
- 2021-08-31
- Completion
- 2021-08-31
- FDA Drug
- Yes
Countries
- United Kingdom
Study Locations
More Related Trials
-
An Exploratory Study of ADR-001 in Patients with Severe Pneumonia Caused by SARS-CoV-2 Infection
NCT04522986 ·Status: COMPLETED ·Phase: PHASE1
-
The Effect of T89 on Improving Oxygen Saturation and Clinical Symptoms in Patients With COVID-19
NCT04285190 ·Status: WITHDRAWN ·Phase: NA
-
ATP and P2X3 Receptor in Chronic Cough
NCT05713019 ·Status: UNKNOWN ·Phase: NA
-
Low-dose Hydroxychloroquine and Bromhexine: a Novel Regimen for COVID-19 Prophylaxis in Healthcare Professionals
NCT04340349 ·Status: UNKNOWN ·Phase: EARLY_PHASE1
-
Study to Assess the Intrapulmonary Pharmacokinetics of SPR206 in Healthy Volunteers
NCT04868292 ·Status: COMPLETED ·Phase: PHASE1
-
Abatacept for Patients With COVID-19 and Respiratory Distress
NCT04477642 ·Status: WITHDRAWN ·Phase: PHASE1/PHASE2
-
Evaluation of the Effects of Bradykinin Antagonists on Pulmonary Manifestations of COVID-19 Infections (AntagoBrad-Cov Study).
NCT05010876 ·Status: COMPLETED ·Phase: PHASE2
-
COmmunity Patients at Risk of Viral Infections Including SARS-CoV-2
NCT04858451 ·Status: TERMINATED ·Phase: PHASE2
-
Clinical Trial to Assess the Efficacy and Safety of Inhaled AQ001S in the Management of Acute COVID-19 Symptoms
NCT05000346 ·Status: TERMINATED ·Phase: PHASE2
-
Testing the Efficacy and Safety of BIO101 for the Prevention of Respiratory Deterioration in COVID-19 Patients
NCT04472728 ·Status: TERMINATED ·Phase: PHASE2/PHASE3
-
Clinical Trial to Evaluate the Effectiveness and Safety of Tocilizumab for Treating Patients With COVID-19 Pneumonia
NCT04445272 ·Status: COMPLETED ·Phase: PHASE2
-
Assessment of the Pharmacokinetics of BLU-5937 Extended Release Prototypes and a BLU-5937 Immediate Release Reference Formulation
NCT05570539 ·Status: COMPLETED ·Phase: PHASE1
-
Study to Evaluate the Safety and Efficacy of ATYR1923 (Efzofitimod) In Participants With Severe Pneumonia Related to COVID-19
NCT04412668 ·Status: COMPLETED ·Phase: PHASE2
-
A Study Estimating The Time Course Of PF-04764793 In The Blood Following Dosing By Oral Inhalation From Dry Powder Inhalers
NCT00928278 ·Status: COMPLETED ·Phase: PHASE1
-
Two-Part Study to Evaluate the Dose Response of SCH 527123 on Sputum Neutrophilia Following Ozone Challenge in Healthy Subjects and Chronic Obstructive Pulmonary Disease (COPD) Patients (P05567 AM7)
NCT01068145 ·Status: TERMINATED ·Phase: PHASE1
-
Sputum Pharmacokinetics of TB Drugs and Bacterial Drug Resistance
NCT02534727 ·Status: COMPLETED
-
A Study of RLS-0071 in Patients With Acute Lung Injury Due to COVID-19 Pneumonia in Early Respiratory Failure
NCT04574869 ·Status: WITHDRAWN ·Phase: PHASE1
-
A Study to Investigate the Safety, Tolerability and Pharmacokinetics of Inhaled CHF10073 After Single and Multiple Doses in Healthy Volunteers and the Effect of Itraconazole on CHF10073 Exposure
NCT06746064 ·Status: COMPLETED ·Phase: PHASE1
-
Safety, Tolerability, Pharmacokinetics and Efficacy of SPR720 for the Treatment of Patients With Mycobacterium Avium Complex (MAC) Pulmonary Disease
NCT04553406 ·Status: TERMINATED ·Phase: PHASE2
-
Study To Estimate The Time Course Of PF-04764793 In The Blood Following Dosing By Oral Inhalation From Dry Powder Inhalers
NCT00977015 ·Status: COMPLETED ·Phase: PHASE1
-
The Safety, Feasibility, and Repeatability of Inhaled ATP Cough Challenges
NCT07085975 ·Status: RECRUITING ·Phase: PHASE1
-
A Study Evaluating the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of SM04646 Inhalation Solution in Subjects With Idiopathic Pulmonary Fibrosis (IPF)
NCT03591926 ·Status: WITHDRAWN ·Phase: PHASE2
-
A Phase II , Placebo-controlled Study to Assess Efficacy of 28 Day Oral AZD9668 in Patients With Bronchiectasis
NCT00769119 ·Status: COMPLETED ·Phase: PHASE2
-
Long-term, Open-label Study of SAR447537 (INBRX-101) in Adults With Alpha-1 Antitrypsin Deficiency Emphysema
NCT05897424 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Study of Micro Dose Ambrisentan in Hospitalized Patients With Respiratory Insufficiency Due to COVID-19
NCT04771000 ·Status: TERMINATED ·Phase: PHASE2