MedTrace Logo

CD8+ T-cell PET/CT Imaging in COVID-19 Patients

NCT04874818 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 5

Last updated 2025-04-02

No results posted yet for this study

Summary

A subset of patients diagnosed with severe acute respiratory syndrome (SARS)-CoV2 infection present with lymphopenia. The degree of lymphopenia, and in particular reduced cluster of differentiation (CD)8+ T-cell numbers, is correlated with clinical deterioration and intensive care unit (ICU) admission. The underlying reasons for lymphopenia in coronavirus disease (COVID)-19 is currently unclear, We aim to assess differences in the in vivo distribution of CD8+ T-cells in patients with proven SARS-CoV2 presenting with lymphopenia or with normal lymphocyte counts, using Zirconium-89 (\[89Zr\])Df-IAB22M2C positron emission tomography (PET) imaging.

Conditions

  • Lymphopenia Due to COVID-19
  • T-cell
  • PET Imaging

Interventions

DIAGNOSTIC_TEST

[89Zr]Df-IAB22M2C PET/CT scan

PET imaging procedure

Sponsors & Collaborators

  • ImaginAb, Inc.

    collaborator INDUSTRY

  • Radboud University Medical Center

    lead OTHER

Eligibility

Min Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-02-14
Primary Completion
2022-12-31
Completion
2022-12-31

Countries

  • Netherlands

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04874818 on ClinicalTrials.gov