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Patient Experiences With the COVID-19 Vaccination After Breast Cancer Treatment

NCT04872738 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 714

Last updated 2026-01-06

Study results available
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Summary

This study aims to elicit patient experiences, choices, and side effects associated with the COVID-19 vaccine after breast cancer surgery. Lymph node swelling is a known and common side effect of both the Moderna and Pfizer COVID-19 vaccines. This is the body's normal reaction to the vaccine. It is worrisome that lymph node swelling after the vaccine mimics that found in breast cancer which has spread to the lymph nodes. This side effect will cause worry and anxiety amongst patients as a result. For patients who have had lymph node removal (axillary lymph node dissection or sentinel lymph node biopsy) and are at risk of lymphedema, the investigators are concerned that the lymph node swelling may tax the lymphatic system and incite lymphedema in those at risk or worsen it in those with BCRL. Fear of lymphedema is high in this population and the investigators need to better understand what risk, if any, lymph node swelling after the COVID-19 vaccine imparts to BCRL risk.

Conditions

  • Breast Cancer Related Lymphedema
  • Covid19

Interventions

OTHER

Survey

Patients in all groups will complete surveys about their experience with the vaccination and any side effects they may have experienced.

Sponsors & Collaborators

  • Massachusetts General Hospital

    lead OTHER

Principal Investigators

  • Alphonse G Taghian, MD, PhD · Massachusetts General Hospital

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-05-07
Primary Completion
2023-03-17
Completion
2023-03-17

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04872738 on ClinicalTrials.gov