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Remotely Supervised tDCS for Slowing ALS Disease Progression

NCT04866771 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 14

Last updated 2025-08-07

Study results available
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Summary

Most ALS care is centered on patient support and symptom management, making rehabilitation an integral aspect for slowing disease progression, prolonging life span, and increasing quality of life. Brain stimulation has been increasingly explored as a promising neuromodulatory tool to prime motor function in several neurological disorders. We propose a novel mechanism using remotely supervised brain stimulation to preserve motor function in individuals with ALS. This project will also aim to explore the effectiveness of brain stimulation on upper and lower motor neuron mechanisms in individuals with ALS.

Conditions

  • Amyotrophic Lateral Sclerosis (ALS)

Interventions

OTHER

Transcranial Direct Current Stimulation (tDCS)

Noninvasive brain stimulation

OTHER

Sham tDCS + anodal tDCS

Fake noninvasive brain stimulation or anodal noninvasive brain stimulation

Sponsors & Collaborators

  • University of Chicago

    collaborator OTHER

  • University of Illinois at Chicago

    lead OTHER

Principal Investigators

  • Sangeetha Madhavan · University of Illinois at Chicago

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-08-27
Primary Completion
2024-07-01
Completion
2025-01-01

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04866771 on ClinicalTrials.gov