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Investigation of Cigarette Cravings in Smokers

NCT04843969 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 76

Last updated 2021-04-14

No results posted yet for this study

Summary

Interventions to disrupt memory reconsolidation have held promise for the treatment of stress- and anxiety-related disorders. In the present study, the investigators will examine whether an intervention based on these principles, called memory updating, could be adapted for reward-seeking behaviors. To test this, non-treatment seeking tobacco smokers will be exposed to smoking cues and/or stress, two stimuli known to trigger smoking. It is predicted that exposure to a stress task will enhance the cues' motivational salience and yield greater susceptibility to the memory updating procedure.

As an add-on, the investigators will examine COVID-associated changes in substance use and whether participants in the memory updating groups might be more resilient to these effects. It is predicted that the changes in substance use will depend on whether the substances are used primarily in social settings.

Conditions

  • Cigarette Smoking
  • Addiction Nicotine
  • Tobacco Use

Interventions

BEHAVIORAL

Stress induction

Exposure to a psychosocial stressor

BEHAVIORAL

Control stress exposure

Exposure to a control task (no stress)

BEHAVIORAL

Cue induction

Exposure to a smoking-related task

BEHAVIORAL

Neutral cue exposure

Exposure to neutral cues

Sponsors & Collaborators

  • Marco Leyton

    lead OTHER

Principal Investigators

  • Marco Leyton, PhD · McGill University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-02-20
Primary Completion
2020-05-01
Completion
2022-01-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04843969 on ClinicalTrials.gov