Trial Outcomes & Findings for Does a Different Local Anesthetic Improve Pain After Carpal Tunnel Release? (NCT NCT04833777)
NCT ID: NCT04833777
Last Updated: 2025-02-10
Results Overview
Severity of pain as measured by the Visual Analogue Scale. This tool asks patients to rate their post-operative pain level from 0 to 10. 0 represents no pain, while 10 represents the worst possible pain.
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
140 participants
Primary outcome timeframe
2 hours post-op
Results posted on
2025-02-10
Participant Flow
Unit of analysis: Wrist
Participant milestones
| Measure |
Lidocaine
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
|---|---|---|
|
Overall Study
STARTED
|
68 68
|
72 72
|
|
Overall Study
Data Analysis
|
67 67
|
72 72
|
|
Overall Study
COMPLETED
|
67 67
|
72 72
|
|
Overall Study
NOT COMPLETED
|
1 1
|
0 0
|
Reasons for withdrawal
| Measure |
Lidocaine
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
|---|---|---|
|
Overall Study
Lost to Follow-up
|
1
|
0
|
Baseline Characteristics
Race and Ethnicity were not collected from any participant.
Baseline characteristics by cohort
| Measure |
Lidocaine
n=67 Participants
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine
n=72 Participants
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Total
n=139 Participants
Total of all reporting groups
|
|---|---|---|---|
|
Age, Continuous
|
58.6 years
STANDARD_DEVIATION 14.9 • n=67 Participants
|
63 years
STANDARD_DEVIATION 16.6 • n=72 Participants
|
60 years
STANDARD_DEVIATION 16 • n=139 Participants
|
|
Sex: Female, Male
Female
|
27 Participants
n=67 Participants
|
35 Participants
n=72 Participants
|
62 Participants
n=139 Participants
|
|
Sex: Female, Male
Male
|
40 Participants
n=67 Participants
|
37 Participants
n=72 Participants
|
77 Participants
n=139 Participants
|
|
Race and Ethnicity Not Collected
|
—
|
—
|
0 Participants
Race and Ethnicity were not collected from any participant.
|
|
Region of Enrollment
Canada
|
67 participants
n=67 Participants
|
72 participants
n=72 Participants
|
139 participants
n=139 Participants
|
PRIMARY outcome
Timeframe: 2 hours post-opSeverity of pain as measured by the Visual Analogue Scale. This tool asks patients to rate their post-operative pain level from 0 to 10. 0 represents no pain, while 10 represents the worst possible pain.
Outcome measures
| Measure |
Lidocaine
n=67 Wrists
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine
n=72 Wrists
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
|---|---|---|---|---|---|---|---|---|
|
Post-operative Pain
|
1.16 score on a scale
Standard Deviation 1.83
|
0.92 score on a scale
Standard Deviation 1.61
|
—
|
—
|
—
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: 4 hours post-opSeverity of pain as measured by the Visual Analogue Scale. This tool asks patients to rate their post-operative pain level from 0 to 10. 0 represents no pain, while 10 represents the worst possible pain.
Outcome measures
| Measure |
Lidocaine
n=67 Wrists
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine
n=72 Wrists
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
|---|---|---|---|---|---|---|---|---|
|
Post-operative Pain
|
2.16 score on a scale
Standard Deviation 2.23
|
1.54 score on a scale
Standard Deviation 1.98
|
—
|
—
|
—
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: 6 hours post-opSeverity of pain as measured by the Visual Analogue Scale. This tool asks patients to rate their post-operative pain level from 0 to 10. 0 represents no pain, while 10 represents the worst possible pain.
Outcome measures
| Measure |
Lidocaine
n=67 wrists
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine
n=72 wrists
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
|---|---|---|---|---|---|---|---|---|
|
Post-operative Pain
|
3.19 score on a scale
Standard Deviation 2.29
|
2.29 score on a scale
Standard Deviation 2.35
|
—
|
—
|
—
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: 8 hours post-opSeverity of pain as measured by the Visual Analogue Scale. This tool asks patients to rate their post-operative pain level from 0 to 10. 0 represents no pain, while 10 represents the worst possible pain.
Outcome measures
| Measure |
Lidocaine
n=67 wrists
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine
n=72 wrists
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
|---|---|---|---|---|---|---|---|---|
|
Post-operative Pain
|
3.87 score on a scale
Standard Deviation 2.24
|
2.92 score on a scale
Standard Deviation 2.30
|
—
|
—
|
—
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: 10 hours post-opSeverity of pain as measured by the Visual Analogue Scale. This tool asks patients to rate their post-operative pain level from 0 to 10. 0 represents no pain, while 10 represents the worst possible pain.
Outcome measures
| Measure |
Lidocaine
n=67 wrists
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine
n=72 wrists
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
|---|---|---|---|---|---|---|---|---|
|
Post-operative Pain
|
3.81 score on a scale
Standard Deviation 2.32
|
3.38 score on a scale
Standard Deviation 2.42
|
—
|
—
|
—
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: 24 hours post-opSeverity of pain as measured by the Visual Analogue Scale. This tool asks patients to rate their post-operative pain level from 0 to 10. 0 represents no pain, while 10 represents the worst possible pain.
Outcome measures
| Measure |
Lidocaine
n=67 wrists
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine
n=72 wrists
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
|---|---|---|---|---|---|---|---|---|
|
Post-operative Pain
|
3.22 score on a scale
Standard Deviation 2.22
|
3.38 score on a scale
Standard Deviation 2.35
|
—
|
—
|
—
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: 24 hoursNumber of Tylenol and Ibuprofen tablets taken post-operatively within the first 24 hours. This was not measured on a scale. Patients were asked to count the total number of Tylenol (500mg) and Ibuprofen (200mg) tablets they consumed within the first 24 hours after surgery.
Outcome measures
| Measure |
Lidocaine
n=67 wrists
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine
n=72 wrists
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
|---|---|---|---|---|---|---|---|---|
|
Post-operative Analgesia Requirements
|
7.45 number of tablets
Standard Deviation 4.70
|
7.31 number of tablets
Standard Deviation 4.57
|
—
|
—
|
—
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: 72 hoursNumber of Tylenol and Ibuprofen tablets taken post-operatively within the first 24 hours. This was not measured on a scale. Patients were asked to count the total number of Tylenol (500mg) and Ibuprofen (200mg) tablets they consumed within the first 72 hours after surgery.
Outcome measures
| Measure |
Lidocaine
n=67 wrists
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine
n=72 wrists
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
|---|---|---|---|---|---|---|---|---|
|
Post-operative Analgesia Requirements
|
14.5 number of tablets
Standard Deviation 11.8
|
13 number of tablets
Standard Deviation 8.9
|
—
|
—
|
—
|
—
|
—
|
—
|
SECONDARY outcome
Timeframe: 2 hours post-opPresence of post-operative numbness in any finger (thumb, index, middle, ring, or little finger). Patients answer "yes" or "no" to numbness.
Outcome measures
| Measure |
Lidocaine
n=67 wrists
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine
n=72 wrists
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
|---|---|---|---|---|---|---|---|---|
|
Post-operative Numbness
|
55 wrists
|
58 wrists
|
—
|
—
|
—
|
—
|
—
|
—
|
SECONDARY outcome
Timeframe: 4 hours post-opPresence of post-operative numbness in any finger (thumb, index, middle, ring, or little finger). Patients answer "yes" or "no" to numbness.
Outcome measures
| Measure |
Lidocaine
n=67 wrists
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine
n=72 wrists
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
|---|---|---|---|---|---|---|---|---|
|
Post-operative Numbness
|
55 wrists
|
64 wrists
|
—
|
—
|
—
|
—
|
—
|
—
|
SECONDARY outcome
Timeframe: 6 hours post-opPresence of post-operative numbness in any finger (thumb, index, middle, ring, or little finger). Patients answer "yes" or "no" to numbness.
Outcome measures
| Measure |
Lidocaine
n=67 wrists
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine
n=72 wrists
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
|---|---|---|---|---|---|---|---|---|
|
Post-operative Numbness
|
43 wrists
|
63 wrists
|
—
|
—
|
—
|
—
|
—
|
—
|
SECONDARY outcome
Timeframe: 8 hours post-opPresence of post-operative numbness in any finger (thumb, index, middle, ring, or little finger). Patients answer "yes" or "no" to numbness.
Outcome measures
| Measure |
Lidocaine
n=67 wrists
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine
n=72 wrists
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
|---|---|---|---|---|---|---|---|---|
|
Post-operative Numbness
|
31 wrists
|
59 wrists
|
—
|
—
|
—
|
—
|
—
|
—
|
SECONDARY outcome
Timeframe: 10 hours post-opPresence of post-operative numbness in any finger (thumb, index, middle, ring, or little finger). Patients answer "yes" or "no" to numbness.
Outcome measures
| Measure |
Lidocaine
n=67 wrists
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine
n=72 wrists
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
|---|---|---|---|---|---|---|---|---|
|
Post-operative Numbness
|
21 wrists
|
51 wrists
|
—
|
—
|
—
|
—
|
—
|
—
|
SECONDARY outcome
Timeframe: 24 hours post-opPresence of post-operative numbness in any finger (thumb, index, middle, ring, or little finger). Patients answer "yes" or "no" to numbness.
Outcome measures
| Measure |
Lidocaine
n=67 wrists
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine
n=72 wrists
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
|---|---|---|---|---|---|---|---|---|
|
Post-operative Numbness
|
17 wrists
|
33 wrists
|
—
|
—
|
—
|
—
|
—
|
—
|
SECONDARY outcome
Timeframe: pre-operative/baseline (immediately before surgery), 3 months after surgeryCarpal tunnel symptoms at 3 months post-op, measured by the Boston Carpal Tunnel Questionnaire. The BCTQ is a self- administered questionnaire consisting of two domains: a symptom severity scale (SSS) and a functional status scale (FSS). Each item on the questionnaire is scored on a 5-point rating scale, with higher scores indicating greater disability. The symptom severity scale ranges from 11 to 55, and the functional status scale ranges from 8 to 40, with higher scores indicating greater disability.
Outcome measures
| Measure |
Lidocaine
n=67 wrists
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine
n=67 wrists
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ SSS
n=72 wrists
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ FSS
n=72 wrists
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ SSS
n=67 wrists
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ FSS
n=67 wrists
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ SSS
n=72 wrists
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ FSS
n=72 wrists
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
|---|---|---|---|---|---|---|---|---|
|
Symptom Change at 3 Months
|
33.1 score on a scale
Standard Deviation 7.1
|
19.6 score on a scale
Standard Deviation 6.4
|
34.5 score on a scale
Standard Deviation 7.1
|
20.7 score on a scale
Standard Deviation 6.4
|
15.3 score on a scale
Standard Deviation 5.9
|
10.5 score on a scale
Standard Deviation 3.8
|
15 score on a scale
Standard Deviation 4.7
|
10.8 score on a scale
Standard Deviation 3.7
|
SECONDARY outcome
Timeframe: 48 hours post-opPresence of post-operative numbness in any finger (thumb, index, middle, ring, or little finger). Patients answer "yes" or "no" to numbness.
Outcome measures
| Measure |
Lidocaine
n=67 wrists
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine
n=72 wrists
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
|---|---|---|---|---|---|---|---|---|
|
Post-operative Numbness
|
13 wrists
|
26 wrists
|
—
|
—
|
—
|
—
|
—
|
—
|
SECONDARY outcome
Timeframe: 72 hours post-opPresence of post-operative numbness in any finger (thumb, index, middle, ring, or little finger). Patients answer "yes" or "no" to numbness.
Outcome measures
| Measure |
Lidocaine
n=67 wrists
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine
n=72 wrists
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-baseline BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Lidocaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous lidocaine as local anesthetic prior to carpal tunnel release (lidocaine intervention)
Local Anesthetics Lidocaine: 10 mL 1% lidocaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ SSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
Bupivacaine-3 Months Post-op BCTQ FSS
Administration of subcutaneous bupivacaine + lidocaine as local anesthetic prior to carpal tunnel release (bupivacaine intervention)
Local Anesthetics Bupivacaine: 5 mL 1% lidocaine with 1:100,000 epinephrine + 5 mL 0.5% bupivacaine with 1:100,000 epinephrine and 1 mL 8.4% sodium bicarbonate
|
|---|---|---|---|---|---|---|---|---|
|
Post-operative Numbness
|
10 wrists
|
24 wrists
|
—
|
—
|
—
|
—
|
—
|
—
|
Adverse Events
Lidocaine
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Bupivacaine
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place